ArticleCerebral cortex (New York, N.Y. : 1991)2009
Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development.
Article in Cerebral cortex (New York, N.Y. : 1991), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- A subpopulation of cortical neurons altered by mutations in the autism risk gene DDX3X.Biology open · 2025Article
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- Gatad2b, associated with the neurodevelopmental syndrome GAND, plays a critical role in neurodevelopment and cortical patterning.Translational psychiatry · 2024Article
- Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes.Cell reports · 2023Article
- Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities.PLoS biology · 2023Article
- Heterogeneous fates of simultaneously-born neurons in the cortical ventricular zone.Scientific reports · 2022Article
- miR-409-3p repressesFrontiers in neuroscience · 2022Article
- Article
- Review
- An evolutionarily acquired microRNA shapes development of mammalian cortical projections.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Combinatorial Developmental Controls on Striatonigral Circuits.Cell reports · 2020Article
- Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity.Nature communications · 2019Article
- Precision in the development of neocortical architecture: From progenitors to cortical networks.Progress in neurobiology · 2019Review
- MicroRNA-Based Separation of Cortico-Fugal Projection Neuron-Like Cells Derived From Embryonic Stem Cells.Frontiers in neuroscience · 2019Article
- Subtype Specification of Cerebral Cortical Neurons in Their Immature Stages.Neurochemical research · 2018Review
- MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex.Brain structure & function · 2017Article
- Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders.Frontiers in molecular neuroscience · 2017Review
- Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Molecular controls over the development of the exceptional neuronal subtype diversity of the cerebral cortex are now beginning to be identified. The initial subtype fate decision early in the life of a neuron, and the malleability of this fate when the balance of key postmitotic signals is modified, reveals not only that a neuron is deterministically set on a general developmental path at its birth, but also that this program must be precisely executed during postmitotic differentiation. Here, we show that callosal projection neurons (CPN) and subcerebral projection neurons (subcerebral PN) in layer V of the neocortex share aspects of molecular identity after their birth that are progressively resolved during differentiation. The LIM-homeodomain-related genes Lmo4 and Clim1 are initially expressed by both CPN and subcerebral PN in layer V, and only during mid to late differentiation does expression of Lmo4 and Clim1 become largely segregated into distinct neuronal subtypes. This progressive postmitotic resolution of molecular identity reveals similarities and possibly shared evolutionary origin between layer V CPN and subcerebral PN, and provides insight into how and when these neuronal subtypes achieve their distinct identities during cortical development.
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