ArticleThe Journal of clinical endocrinology and metabolism2009
Growth hormone deficiency is associated with decreased quality of life in patients with prior acromegaly.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00182091 (Effects of Physiologic Growth Hormone Administration on Cardiovascular Risk in Subjects With Growth Hormone Deficiency Following Cure of Acromegaly), which is not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Physiologic Growth Hormone Administration on Cardiovascular Risk in Subjects With Growth Hormone Deficiency Following Cure of Acromegaly
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Psychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature.Pituitary · 2025Pooled it
- The Insulin-like Growth Factor Family as a Potential Peripheral Biomarker in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Anxiety, depression and acromegaly: a systematic review.Journal of endocrinological investigation · 2025Pooled it
- Quality of life (QoL) impairments in patients with a pituitary adenoma: a systematic review of QoL studies.Pituitary · 2015Pooled it
- Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement.The Journal of clinical endocrinology and metabolism · 2010Trial
- Effect of growth hormone replacement therapy on the quality of life in women with growth hormone deficiency who have a history of acromegaly versus other disorders.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsTrial
- Article
- Quality of life questionnaires in patients with acromegaly: a scoping review.Journal of patient-reported outcomes · 2026Article
- Neuroendocrine Disruptions Following Head Injury.Current neurology and neuroscience reports · 2023Review
- Article
- Effects of growth hormone receptor antagonism and somatostatin analog administration on quality of life in acromegaly.Clinical endocrinology · 2021Article
- Sleep disturbance and delirium in patients with acromegaly in the early postoperative period after transsphenoidal pituitary surgery.Medicine · 2020Article
- Updates in rare and not-so-rare complications of acromegaly: focus on respiratory function and quality of life in acromegaly.F1000Research · 2020Review
- Article
- Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors.Frontiers in endocrinology · 2018Article
- Update on quality of life in patients with acromegaly.Pituitary · 2017Review
- Insulin-like growth factor 1 and risk of depression in older people: the English Longitudinal Study of Ageing.Translational psychiatry · 2016Article
- Effect of growth hormone treatment on diastolic function in patients who have developed growth hormone deficiency after definitive treatment of acromegaly.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2016Observational
- Article
- Short-term efficacy of recombinant human GH therapy in cured acromegaly patients with GH deficiency: a single-center experience.Endocrine connections · 2015Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
contextBoth GH deficiency (GHD) and GH excess are associated with a decreased quality of life. However, it is unknown whether patients with GHD after treatment for acromegaly have a poorer quality of life than those with normal GH levels after cure of acromegaly.
objectiveThe aim of the study was to determine whether patients with GHD and prior acromegaly have a poorer quality of life than those with GH sufficiency after cure of acromegaly. DESIGN AND
settingWe conducted a cross-sectional study in a General Clinical Research Center. STUDY
participantsForty-five patients with prior acromegaly participated: 26 with GHD and 19 with GH sufficiency.
interventionThere were no interventions.
main outcome measuresWe evaluated quality of life, as measured by 1) the Quality of Life Adult Growth Hormone Deficiency Assessment (QoL-AGHDA); 2) the Short-Form Health Survey (SF-36); and 3) the Symptom Questionnaire.
resultsMean scores on all subscales of all questionnaires, except for the anger/hostility and anxiety subscales of the Symptom Questionnaire, showed significantly impaired quality of life in the GH-deficient group compared with the GH-sufficient group. Peak GH levels after GHRH-arginine stimulation levels were inversely associated with QoL-AGHDA scale scores (R = -0.53; P = 0.0005) and the Symptom Questionnaire Depression subscale scores (R = -0.35; P = 0.031) and positively associated with most SF-36 subscale scores.
conclusionsOur data are the first to demonstrate a reduced quality of life in patients who develop GHD after cure of acromegaly compared to those who are GH sufficient. Further studies are warranted to determine whether GH replacement would improve quality of life for patients with GHD after cure from acromegaly.
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