ArticleClinical cancer research : an official journal of the American Association for Cancer Research2009
Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Genome-wide association study identifies a genetic variant associated with risk for more aggressive prostate cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Trial
- Cumulative Effect Assessment of Common Genetic Variants on Prostate Cancer: Preliminary Studies.Biomedicines · 2022Article
- Article
- Contribution ofOncotarget · 2019Article
- Impact of prostate-specific antigen on a baseline prostate cancer risk assessment including genetic risk.Urology · 2015Article
- NUDT11 rs5945572 polymorphism and prostate cancer risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Imaging and Markers as Novel Diagnostic Tools in Detecting Insignificant Prostate Cancer: A Critical Overview.International scholarly research notices · 2014Review
- Common variants at 8q24 are associated with prostate cancer risk in Serbian population.Pathology oncology research : POR · 2013Article
- Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression.Human mutation · 2013Article
- Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial.European urology · 2012Article
- Using graded response model for the prediction of prostate cancer risk.Human genetics · 2012Article
- Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.Oncogene · 2012Article
- Evaluation of multiple risk-associated single nucleotide polymorphisms versus prostate-specific antigen at baseline to predict prostate cancer in unscreened men.European urology · 2012Article
- A comparison of Bayesian and frequentist approaches to incorporating external information for the prediction of prostate cancer risk.Genetic epidemiology · 2012Article
- Article
- Genetic variation in RNASEL and risk for prostate cancer in a population-based case-control study.The Prostate · 2011Article
- Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Article
- Genome-wide copy-number variation analysis identifies common genetic variants at 20p13 associated with aggressiveness of prostate cancer.Carcinogenesis · 2011Article
- Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels.Carcinogenesis · 2011Article
- Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.The Prostate · 2011Article
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Authors and funding
6 authors.
Funding
Abstract
purposeTwo recent genome-wide association studies have highlighted several single nucleotide polymorphisms (SNPs) purported to be associated with prostate cancer risk. We investigated the significance of these SNPs in a population-based study of Caucasian men, testing the effects of each SNP in relation to family history of prostate cancer and the clinicopathologic features of the disease. EXPERIMENTAL
designWe genotyped 13 SNPs in 1,308 prostate cancer patients and 1,267 unaffected controls frequency matched to cases by five-year age groups. The association of each SNP with disease risk stratified by family history of prostate cancer and clinicopathologic features of the disease was calculated with the use of logistic and polytomous regression.
resultsThese results confirm the importance of multiple, previously reported SNPs in relation to prostate cancer susceptibility; 11 of the 13 SNPs were significantly associated with risk of developing prostate cancer. However, none of the SNP associations were of comparable magnitude with that associated with having a first-degree family history of the disease. Risk estimates associated with SNPs rs4242382 and rs2735839 varied by family history, whereas risk estimates for rs10993994 and rs5945619 varied by Gleason score.
conclusionsOur results confirm that several recently identified SNPs are associated with prostate cancer risk; however, the variant alleles only confer a low to moderate relative risk of disease and are generally not associated with more aggressive disease features.
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