ArticleVascular medicine (London, England)2009
Total serum bilirubin does not affect vascular reactivity in patients with diabetes.
Article in Vascular medicine (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of Age and Sex on Systemic Inflammation and Cardiometabolic Function in Individuals With Type 2 Diabetes.Journal of the American Heart Association · 2025Article
- Article
- Impaired vascular relaxation in type 2 diabetes: A systematic review and meta-analysis.EXCLI journal · 2024Review
- Low-normal serum unconjugated bilirubin levels are associated with late but not early carotid atherosclerotic lesions in T2DM subjects.Frontiers in endocrinology · 2022Article
- Are total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Bilirubin and Endothelial Function.Journal of atherosclerosis and thrombosis · 2019Review
- Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population.Therapeutic advances in chronic disease · 2015Review
- Inverse association between serum bilirubin levels and arterial stiffness in Korean women with type 2 diabetes.PloS one · 2014Article
- Low-normal free thyroxine confers decreased serum bilirubin in type 2 diabetes mellitus.Thyroid : official journal of the American Thyroid Association · 2013Article
- The Relationship among Homocysteine, Bilirubin, and Diabetic Retinopathy.Diabetes & metabolism journal · 2011Article
- Effects of diabetes and obesity on vascular reactivity, inflammatory cytokines, and growth factors.Obesity (Silver Spring, Md.) · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Bilirubin may have a major role in the prevention of cardiovascular disease based on recent data regarding its anti-oxidant properties. We determined the relationship between total serum bilirubin and vascular reactivity in a large cohort of individuals with diabetes, a disease associated with known oxidant stress. We studied 302 individuals: 52 controls, 37 with type 1 diabetes, 213 with type 2 diabetes. High-resolution ultrasound was used to measure flow-mediated dilation (FMD; endothelium-dependent) and nitroglycerin-induced dilation (NID, endothelium-independent) of the brachial artery. Laser Doppler perfusion imaging was used to measure microvascular reactivity in the forearm skin before and after iontophoresis of acetylcholine (endothelium-dependent) and sodium nitroprusside (endothelium-independent). Bilirubin levels were higher in the type 2 diabetes group (0.71 +/- 0.34 mg/dl) compared to controls (0.56 +/- 0.26 mg/dl, p < 0.0001). A weak inverse correlation was observed between bilirubin and FMD (r = -0.125, p = 0.032) and skin endothelium-dependent vasodilation (r = -0.157, p = 0.019). In multivariate analyses, however, these correlations were not statistically significant. There is no association between bilirubin levels and vascular reactivity in the macro- and microcirculation of individuals with diabetes. Bilirubin, therefore, does not correlate with predictors of cardiovascular risk in the diabetic population.
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Registered trials
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