ReviewPhysiological genomics2009
Lung evolution as a cipher for physiology.
Review in Physiological genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Non-Random Genome Editing and Natural Cellular Engineering in Cognition-Based Evolution.Cells · 2021Review
- Reappraising the exteriorization of the mammalian testes through evolutionary physiology.Communicative & integrative biology · 2019Review
- Life is determined by its environment.International journal of astrobiology · 2016Article
- Article
- Life Is Simple-Biologic Complexity Is an Epiphenomenon.Biology · 2016Article
- Article
- A central theory of biology.Medical hypotheses · 2015Article
- Article
- The lung alveolar lipofibroblast: an evolutionary strategy against neonatal hyperoxic lung injury.Antioxidants & redox signaling · 2014Review
- Evolution and Cell Physiology. 1. Cell signaling is all of biology.American journal of physiology. Cell physiology · 2013Review
- Comparative molecular developmental aspects of the mammalian- and the avian lungs, and the insectan tracheal system by branching morphogenesis: recent advances and future directions.Frontiers in zoology · 2012Article
- PPARγ Signaling Mediates the Evolution, Development, Homeostasis, and Repair of the Lung.PPAR research · 2012Article
- Curcumin augments lung maturation, preventing neonatal lung injury by inhibiting TGF-β signaling.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- A cell-molecular approach predicts vertebrate evolution.Molecular biology and evolution · 2011Article
- Antenatally administered PPAR-gamma agonist rosiglitazone prevents hyperoxia-induced neonatal rat lung injury.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Leptin integrates vertebrate evolution: from oxygen to the blood-gas barrier.Respiratory physiology & neurobiology · 2010Review
- The Evolution of Cell Communication: The Road not Taken.Cell communication insights · 2009Article
- What We Talk About When We Talk About Evolution.Cell communication insightsArticle
- On the evolution of development.Trends in developmental biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In the postgenomic era, we need an algorithm to readily translate genes into physiologic principles. The failure to advance biomedicine is due to the false hope raised in the wake of the Human Genome Project (HGP) by the promise of systems biology as a ready means of reconstructing physiology from genes. like the atom in physics, the cell, not the gene, is the smallest completely functional unit of biology. Trying to reassemble gene regulatory networks without accounting for this fundamental feature of evolution will result in a genomic atlas, but not an algorithm for functional genomics. For example, the evolution of the lung can be "deconvoluted" by applying cell-cell communication mechanisms to all aspects of lung biology development, homeostasis, and regeneration/repair. Gene regulatory networks common to these processes predict ontogeny, phylogeny, and the disease-related consequences of failed signaling. This algorithm elucidates characteristics of vertebrate physiology as a cascade of emergent and contingent cellular adaptational responses. By reducing complex physiological traits to gene regulatory networks and arranging them hierarchically in a self-organizing map, like the periodic table of elements in physics, the first principles of physiology will emerge.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.