Evidence map›Paper›PMID 19366676›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2009

A randomized trial of the effect of estrogen and testosterone on economic behavior.

Niklas Zethraeus, Ljiljana Kocoska-Maras, Tore Ellingsen, Bo von Schoultz, Angelica Lindén Hirschberg, Magnus Johannesson

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03210558 (Effects of Moderately Increased Testosterone Concentration on Physical Performance and Behaviour in Healthy Women - a Double-blind, Randomized, Placebo-controlled Study), which is not on this map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03210558 phase2completednot on this mapstarted 2017, after this paper: background citation

Effects of Moderately Increased Testosterone Concentration on Physical Performance and Behaviour in Healthy Women - a Double-blind, Randomized, Placebo-controlled Study

TypeinterventionalSponsorKarolinska University HospitalRan2017 to 2018Enrolled48ConditionsAthletic Performance, Testosterone, Women's Health: Female Athlete/Female Athlete TriadArmsTestosterone cream 1% (Andro-Feme® ), Placebo cream
3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Investigating the effects of single-dose intranasal testosterone on economic preferences in a large randomized trial of men.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  3. Testosterone causes both prosocial and antisocial status-enhancing behaviors in human males.Proceedings of the National Academy of Sciences of the United States of America · 2016
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  10. Review
  11. Masculinity and Lying.Frontiers in psychology · 2021
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  20. Sex Hormone/Cortisol Ratios Differentially Modulate Risk-Taking in Men and Women.Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Niklas ZethraeusDepartment of Economics, Stockholm School of Economics, Box 6501, SE-113 83 Stockholm, Sweden.
Ljiljana Kocoska-Maras
Tore Ellingsen
Bo von Schoultz
Angelica Lindén Hirschberg
Magnus Johannesson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Existing correlative evidence suggests that sex hormones may affect economic behavior such as risk taking and reciprocal fairness. To test this hypothesis we conducted a double-blind randomized study. Two-hundred healthy postmenopausal women aged 50-65 years were randomly allocated to 4 weeks of treatment with estrogen, testosterone, or placebo. At the end of the treatment period, the subjects participated in a series of economic experiments that measure altruism, reciprocal fairness, trust, trustworthiness, and risk attitudes. There was no significant effect of estrogen or testosterone on any of the studied behaviors.

Indexed as

EconomicsAgedAltruismBehaviorDouble-Blind MethodEstrogensFemaleHumansMiddle AgedPlacebosRisk-TakingTestosteroneEstrogensPlacebosTestosterone

Identifiers

PMID19366676
PMCPMC2666090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.