Evidence map›Paper›PMID 19366371›Full record

ArticleExperimental dermatology2009

Expression of COUP-TF-interacting protein 2 (CTIP2) in human atopic dermatitis and allergic contact dermatitis skin.

Gitali Ganguli-Indra, Xiaobo Liang, Stephen Hyter, Mark Leid, Jon Hanifin, Arup K Indra

Open access · bronzeAbstract readLetter
In one paragraph

Article in Experimental dermatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System.Frontiers in cell and developmental biology · 2020
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gitali Ganguli-Indra
Xiaobo Liang
Stephen Hyter
Mark Leid
Jon Hanifin
Arup K Indra
Oregon State University · USOregon Health & Science University · US

Funding

Reducing Susceptibility to Environmental Stress Throughout the Life SpanP30ES000210 · NIEHS · OREGON STATE UNIVERSITY · PI BECKMAN, JOSEPH S · 1985 to 2015
$21.4M
Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation, R01AR056008 · NIAMS · OREGON STATE UNIVERSITY · PI INDRA, ARUP K. · 2008 to 2012
$1.5M
NIAMS NIH HHS R01 AR056008NIAMS NIH HHS R01AR056008NIEHS NIH HHS ES00210NIEHS NIH HHS P30 ES000210
6 · The paper itself

Abstract

Chicken ovalbumin upstream promoter-transcription factor-interacting protein 2 (CTIP2) is a transcriptional regulator that is highly expressed in skin during mouse development, as well as in proliferating cells of adult mouse skin. We investigated expression of CTIP2 along with proliferation marker Ki-67 in normal human skin, and in skin from atopic dermatitis (AD), and in allergic contact dermatitis (ACD) samples by immunohistochemistry (IHC). We discovered for the first time that CTIP2 was expressed in proliferating basal and suprabasal layer in normal human epidermis. CTIP2 expression was dramatically increased in the epidermis from the AD and ACD samples compared with normal samples, and was labelled in both proliferating basal and suprabasal layers. Altogether our results suggest that CTIP2 expression could be linked to disease progression and/or maintenance in AD and ACD patients.

Indexed as

Gene Expression Regulation, EnzymologicAnimalsBiopsyCell DifferentiationCell ProliferationDermatitis, AtopicDermatitis, ContactDisease ProgressionGene Expression ProfilingHumansImmunohistochemistryKi-67 AntigenMiceRepressor ProteinsTranscription, GeneticTumor Suppressor ProteinsBCL11B protein, humanKi-67 AntigenRepressor ProteinsTumor Suppressor Proteins

Identifiers

PMID19366371
PMCPMC2783464
OpenAlexW2064472751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.