Evidence map›Paper›PMID 19365730›Full record

ArticleBiomedical microdevices2009

The application of on-chip optofluidic microscopy for imaging Giardia lamblia trophozoites and cysts.

Lap Man Lee, Xiquan Cui, Changhuei Yang

Abstract read
In one paragraph

Article in Biomedical microdevices, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Lensfree On-Chip Microscopy and Tomography for Bio-Medical Applications.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society · 2011
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lap Man LeeDepartment of Bioengineering (MC138-78), California Institute of Technology, Pasadena, CA 91125, USA. lmlee@caltech.edu
Xiquan Cui
Changhuei Yang

Funding

Differential Interference Contrast Optofluidic MicroscopyR21EB008867 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI YANG, CHANGHUEI · 2008 to 2009
$388k
NIBIB NIH HHS R21 EB008867NIBIB NIH HHS R21EB008867-01
6 · The paper itself

Abstract

The optofluidic microscope (OFM) is a lensless, low-cost and highly compact on-chip device that can enable high-resolution microscopy imaging. The OFM performs imaging by flowing/scanning the target objects across a slanted hole array; by measuring the time-varying light transmission changes through the holes, we can then render images of the target objects at a resolution that is comparable to the holes' size. This paper reports the adaptation of the OFM for imaging Giardia lamblia trophozoites and cysts, a disease-causing parasite species that is commonly found in poor-quality water sources. We also describe our study of the impact of pressure-based flow and DC electrokinetic-based flow in controlling the flow motion of Giardia cysts--rotation-free translation of the parasite is important for good OFM image acquisition. Finally, we report the successful microscopy imaging of both Giardia trophozoites and cysts with an OFM that has a focal plane resolution of 0.8 microns.

Indexed as

Optical DevicesEquipment DesignGiardia lambliaMicrofluidic Analytical TechniquesMicroscopyMolecular ImagingPressureTrophozoites

Identifiers

PMID19365730
PMCPMC2888668

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.