ArticleMolecular biology reports2010
Association of LT-alpha Ala252Gly gene polymorphism and the genetic predisposition of coronary heart disease in Chinese.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Associations of lymphotoxin-a (LTA) rs909253 A/G gene polymorphism, plasma level and risk of ankylosing spondylitis in a Chinese Han population.Scientific reports · 2020Article
- Association of IL-10-1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population.Molecular biology reports · 2012Article
- Role of tissue plasminogen activator and plasminogen activator inhibitor polymorphism in myocardial infarction.Molecular biology reports · 2011Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About the role of lymphotoxin alpha (LTA) gene in coronary heart disease, controversy reports exists. So the purpose of the present study was to investigate the possible involvement of LTA in the pathogenesis of atherosclerosis and MI in Chinese. In a cross-sectional design, we studied 57 coronary heart disease patients with family history of coronary heart disease and in another control group of 62 healthy subjects (mean age 56 years; range 32-78 years). Body mass index, the levels of blood pressure, the plasma levels of lipoproteins, cholesterol, and triglycerides were measured, smoking data were self-reported, and LTA genotypes were determined. LTA Ala252Gly gene polymorphism had two alleles (LTA1 and LTA2) and three kinds of genotype: homozygote LTA G/G, LTA A/A, and heterozygote LTA A/G. No population significant differences were detected in LTA genotypes and allele frequencies between coronary heart disease patients or healthy controls (chi(2) = 1.479, P = 0.477 > 0.05). LTA Ala252Gly gene polymorphism was not associated with the genetic predisposition of coronary heart disease.
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