Trial reportPediatric cardiology2009
Natriuretic peptide as an adjunctive diagnostic test in the acute phase of Kawasaki disease.
Trial report in Pediatric cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis.BMJ open · 2015Pooled it
- Biomarkers in Primary Systemic Vasculitides: Narrative Review.International journal of molecular sciences · 2026Review
- Cardiac Biomarkers Aid in Differentiation of Kawasaki Disease from Multisystem Inflammatory Syndrome in Children Associated with COVID-19.Pediatric cardiology · 2025Article
- A decision tree model for predicting intravenous immunoglobulin resistance and coronary artery involvement in Kawasaki disease.BMC pediatrics · 2022Article
- Cardiac Biomarkers in Pediatrics: An Undervalued Resource.Clinical chemistry · 2021Review
- Serum Ferritin as a Diagnostic Biomarker for Kawasaki Disease.Annals of laboratory medicine · 2021Article
- Kawasaki Disease: an Update.Current rheumatology reports · 2020Review
- Distinguishing Kawasaki Disease from Febrile Infectious Disease Using Gene Pair Signatures.BioMed research international · 2020Article
- The role of age-specific N-terminal pro-brain natriuretic peptide cutoff values in predicting intravenous immunoglobulin resistance in Kawasaki disease: a prospective cohort study.Pediatric rheumatology online journal · 2019Article
- Utilization of Coronary Artery to Aorta for the Early Detection of Kawasaki Disease.Pediatric cardiology · 2019Article
- MiR-222-3p in Platelets Serves as a Distinguishing Marker for Early Recognition of Kawasaki Disease.Frontiers in pediatrics · 2019Article
- A Decade of NT-proBNP in Acute Kawasaki Disease, from Physiological Response to Clinical Relevance.Children (Basel, Switzerland) · 2018Review
- Differentiation between incomplete Kawasaki disease and secondary hemophagocytic lymphohistiocytosis following Kawasaki disease using N-terminal pro-brain natriuretic peptide.Korean journal of pediatrics · 2018Article
- Factors Predicting Resistance to Intravenous Immunoglobulin Treatment and Coronary Artery Lesion in Patients with Kawasaki Disease: Analysis of the Korean Nationwide Multicenter Survey from 2012 to 2014.Korean circulation journal · 2018Article
- C-reactive protein and N-terminal pro-brain natriuretic peptide discrepancy: a differentiation of adenoviral pharyngoconjunctival fever from Kawasaki disease.Korean journal of pediatrics · 2018Article
- The Efficacy and Safety of High-Dose Intravenous Immunoglobulin in the Treatment of Kawasaki Disease: How Can We Predict Resistance to Intravenous Immunoglobulin Treatment of Kawasaki Disease?Korean circulation journal · 2017Article
- N-terminal pro-brain natriuretic peptide can be an adjunctive diagnostic marker of hyper-acute phase of Kawasaki disease.European journal of pediatrics · 2016Article
- Predictive factors of resistance to intravenous immunoglobulin and coronary artery lesions in Kawasaki disease.Korean journal of pediatrics · 2016Article
- Pro-brain natriuretic peptide (ProBNP) levels in North Indian children with Kawasaki disease.Rheumatology international · 2016Article
- Timing of Dynamic NT-proBNP and hs-cTnT Response to Exercise Challenge in Asymptomatic Children with Moderate Aortic Valve Regurgitation or Moderate Aortic Valve Stenosis.Pediatric cardiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary arteritis rather than myocardial involvement is typically emphasized in Kawasaki disease (KD). Moreover, the criteria and the usual biological markers oversee the importance of cardiac-specific markers in diagnosing this disease. We sought to study the clinical usefulness of measuring B-type natriuretic peptide (BNP) and its N-terminal moiety (NT-proBNP) at the onset of KD. Our objective was to evaluate blood concentrations of BNP and NT-proBNP during the acute and subacute phases of KD. We conducted a prospective study comparing newly diagnosed KD patients to non-KD febrile controls. Blood specimens were collected at presentation, 6-12 h after intravenous immunoglobulin (IVIG) therapy, 1-2 weeks later, and 2-3 months later, or only upon reenrollment for controls. Forty-there KD and 19 control patients were enrolled consecutively. The mean age was 47.1 +/- 34.3 and 62.2 +/- 44.9 months, respectively (p = NS). Pre-IVIG NT-proBNP levels were significantly higher in KD patients than in controls (923.6 +/- 1361.7 vs. 186.2 +/- 198.0 ng/L; p < 0.001), with no statistical difference for BNP (141.9 +/- 227.5 vs. 59.9 +/- 72.4 ng/L; p = 0.112). In conclusion, our data indicate that NT-proBNP is a better marker of myocardial involvement in acute KD than BNP, particularly in cases with incomplete diagnostic criteria, and suggest that it may be a valid adjunctive diagnostic method to support the diagnosis of KD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.