Evidence map›Paper›PMID 19365280›Full record

ReviewJournal of cardiovascular pharmacology2009

Ion channels, transporters, and pumps as targets for heart failure therapy.

Darshan Doshi, Steven O Marx

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cardiovascular pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Multi-modal tissue-aware graph neural network forbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Ischemic Heart Disease and Heart Failure: Role of Coronary Ion Channels.International journal of molecular sciences · 2020
    Review
  5. Review
  6. ProBLM web server: protein and membrane placement and orientation package.Computational and mathematical methods in medicine · 2014
    Article
  7. The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium.American journal of physiology. Heart and circulatory physiology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Darshan DoshiDivision of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Steven O Marx
Columbia University · US

Funding

Ion channel regulation by macromolecular complexesR01HL068093 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARX, STEVEN O · 2001 to 2010
$2.4M
NHLBI NIH HHS R01 HL068093NHLBI NIH HHS R01 HL68093
6 · The paper itself

Abstract

Congestive heart failure is a leading cause of morbidity and mortality. Congestive heart failure is marked by atrial and ventricular enlargements and reduced cardiac contractility and an association with an increased incidence of atrial and ventricular arrhythmias and sudden cardiac death. Dysfunctional ion channel function is one of the major underlying mechanisms of the reduced contractility and arrhythmias. In this review, we explore the utility of ion channels, transporters, and pumps as targets for the treatment of heart failure, focusing predominantly on the treatment for reduced contractility and arrhythmias.

Indexed as

AnimalsArrhythmias, CardiacHeart FailureHumansIon Channel GatingIon ChannelsMyocardial ContractionIon Channels

Identifiers

PMID19365280
PMCPMC2766421
OpenAlexW2008586480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.