ArticleProceedings of the National Academy of Sciences of the United States of America2009
Averting epidemics of extensively drug-resistant tuberculosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review.PLoS pathogens · 2024Pooled it
- Population-level mathematical modeling of antimicrobial resistance: a systematic review.BMC medicine · 2019Pooled it
- Quantifying TB transmission: a systematic review of reproduction number and serial interval estimates for tuberculosis.Epidemiology and infection · 2018Pooled it
- Effects of Fluroquinolones in Newly Diagnosed, Sputum-Positive Tuberculosis Therapy: A Systematic Review and Network Meta-Analysis.PloS one · 2015Pooled it
- The diagnostic accuracy of the GenoType(®) MTBDRsl assay for the detection of resistance to second-line anti-tuberculosis drugs.The Cochrane database of systematic reviews · 2014Pooled it
- Yield of contact investigations in households of patients with drug-resistant tuberculosis: systematic review and meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Pooled it
- Modeling of novel diagnostic strategies for active tuberculosis - a systematic review: current practices and recommendations.PloS one · 2014Pooled it
- Frequent Suboptimal Thermocycler Ramp Rate Usage Negatively Impacts GenoType MTBDRsl VER 2.0 Performance for Second-Line Drug-Resistant Tuberculosis Diagnosis.The Journal of molecular diagnostics : JMD · 2022Article
- A qualitative meta-synthesis of facilitators and barriers to tuberculosis diagnosis and treatment in Nigeria.BMC public health · 2021Article
- Nosocomial tuberculosis transmission from 2006 to 2018 in Beijing Chest Hospital, China.Antimicrobial resistance and infection control · 2020Article
- Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A Methodology for Determining Which Diseases Warrant Care in a High-Level Containment Care Unit.Viruses · 2019Article
- Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling.The Lancet. Infectious diseases · 2019Article
- Underestimated Manipulative Roles ofFrontiers in immunology · 2019Review
- Modeling the patient and health system impacts of alternative xpert® MTB/RIF algorithms for the diagnosis of pulmonary tuberculosis in Addis Ababa, Ethiopia.BMC infectious diseases · 2017Article
- Integrated Tuberculosis/Human Immunodeficiency Virus Community-Based Case Finding in Rural South Africa: Implications for Tuberculosis Control Efforts.Open forum infectious diseases · 2017Article
- GenoTypeThe Cochrane database of systematic reviews · 2016Review
- Treatment Outcomes for Patients with Extensively Drug-Resistant Tuberculosis, KwaZulu-Natal and Eastern Cape Provinces, South Africa.Emerging infectious diseases · 2016Article
- Cost-Effectiveness of Community-Based TB/HIV Screening and Linkage to Care in Rural South Africa.PloS one · 2016Article
- Translating the Tuberculosis Research Agenda: Much Accomplished, but Much More to Be Done.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Extensively drug-resistant tuberculosis (XDR TB) has been detected in most provinces of South Africa, particularly in the KwaZulu-Natal province where several hundred cases have been reported since 2004. We analyzed the transmission dynamics of XDR TB in the region using mathematical models, and observed that nosocomial transmission clusters of XDR TB may emerge into community-based epidemics under the public health conditions of many South African communities. The effective reproductive number of XDR TB in KwaZulu-Natal may be around 2. Intensified community-based case finding and therapy appears critical to curtailing transmission. In the setting of delayed disease presentation and high system demand, improved diagnostic approaches may need to be employed in community-based programs rather than exclusively at tertiary hospitals. Using branching process mathematics, we observed that early, community-based drug-susceptibility testing and effective XDR therapy could help curtail ongoing transmission and reduce the probability of XDR TB epidemics in neighboring territories.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.