ArticleProceedings of the National Academy of Sciences of the United States of America2009
A right-sided pathway involving FGF8/Snai1 controls asymmetric development of the proepicardium in the chick embryo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Foxf1-mediated co-regulation of miR-495 and let-7c modulates epicardial cell migration and myocardial specification.Cellular and molecular life sciences : CMLS · 2025Article
- Mef2c- and Nkx2-5-Divergent Transcriptional Regulation of Chick WT1_76127 and Mouse Gm14014 lncRNAs and Their Implication in Epicardial Cell Migration.International journal of molecular sciences · 2024Article
- Mitral valve repair in patients with mirror-image dextrocardia and situs inversus: two cases and a review of the literature.The Journal of international medical research · 2023Review
- Tbx18 Orchestrates Cytostructural Transdifferentiation of Cardiomyocytes to Pacemaker Cells by Recruiting the Epithelial-Mesenchymal Transition Program.Journal of proteome research · 2022Article
- The Role of Bmp- and Fgf Signaling Modulating Mouse Proepicardium Cell Fate.Frontiers in cell and developmental biology · 2021Article
- Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish.Histology and histopathology · 2020Article
- The Chicken as a Model Organism to Study Heart Development.Cold Spring Harbor perspectives in biology · 2020Review
- Spontaneous Left Cardiac Isomerism in Chick Embryos: Case Report, Review of the Literature, and Possible Significance for the Understanding of Ventricular Non-Compaction Cardiomyopathy in the Setting of Human Heterotaxy Syndromes.Journal of cardiovascular development and disease · 2019Article
- ISM1 regulates NODAL signaling and asymmetric organ morphogenesis during development.The Journal of cell biology · 2019Article
- Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains.Scientific reports · 2018Article
- Article
- Current Perspectives in Cardiac Laterality.Journal of cardiovascular development and disease · 2016Review
- Probing early heart development to instruct stem cell differentiation strategies.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish.Molecular medicine reports · 2016Article
- The Early Stages of Heart Development: Insights from Chicken Embryos.Journal of cardiovascular development and disease · 2016Review
- The Lhx9-integrin pathway is essential for positioning of the proepicardial organ.Development (Cambridge, England) · 2016Article
- Article
- Induction of the Proepicardium.Journal of developmental biology · 2013Article
- Snai1 is important for avian epicardial cell transformation and motility.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Epicardial progenitor cells in cardiac development and regeneration.Journal of cardiovascular translational research · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proepicardium (PE) is a transient structure that forms at the venous pole of the embryonic vertebrate heart. This cardiac progenitor cell population gives rise to the epicardium, coronary vasculature, and fibroblasts. In the chicken embryo, the PE displays left-right (L-R) asymmetry and develops only on the right side, while on the left only a vestigial PE is formed, which subsequently gets lost by apoptosis. In this study, we analyzed how the L-R asymmetry pathway affects PE formation. Experimental manipulation of left-side determinants such as Shh, Nodal, and Cfc as well as forced expression of Pitx2 had no effect on the sidedness of PE development. In contrast, inhibition of early-acting regulators of L-R axis formation such as H(+)/K(+)-ATPase or primitive streak apoptosis affected the sidedness of PE development. Experimental interference with the right-side determinants Fgf8 or Snai1 prevented PE formation, whereas ectopic left-sided expression of Fgf8 or Snai1 resulted in bilateral PE development. These data provide novel insight into the molecular control of asymmetric morphogenesis suggesting that also the right side harbors an instructive signaling pathway that is involved in the control of PE development. This pathway might be of general relevance for setting up L-R asymmetries at the venous pole of the heart.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.