ReviewArchives of ophthalmology (Chicago, Ill. : 1960)2009
Stem cells as tools in regenerative therapy for retinal degeneration.
Review in Archives of ophthalmology (Chicago, Ill. : 1960), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- The human lens is capable of trilineage differentiation towards osteo-, chondro-, and adipogenesis-a model for studying cataract pathogenesis.Frontiers in bioengineering and biotechnology · 2023Article
- Potential of Müller Glial Cells in Regeneration of Retina; Clinical and Molecular Approach.International journal of organ transplantation medicine · 2022Review
- Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors.Stem cell research & therapy · 2020Article
- Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma.Tissue engineering and regenerative medicine · 2020Review
- Retinal stem cell transplantation: Balancing safety and potential.Progress in retinal and eye research · 2020Review
- Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways.Molecular biotechnology · 2019Review
- Insights from Genetic Model Systems of Retinal Degeneration: Role of Epsins in Retinal Angiogenesis and VEGFR2 Signaling.Journal of nature and science · 2017Article
- Advances in bone marrow stem cell therapy for retinal dysfunction.Progress in retinal and eye research · 2017Review
- Cellular models and therapies for age-related macular degeneration.Disease models & mechanisms · 2015Review
- The potential role of regenerative medicine in the man-agement of traumatic patients.Journal of injury & violence research · 2015Article
- Selectivity of direct and network-mediated stimulation of the retinal ganglion cells with epi-, sub- and intraretinal electrodes.Journal of neural engineering · 2014Article
- Wharton's jelly mesenchymal stem cells differentiate into retinal progenitor cells.Neural regeneration research · 2013Article
- Association between multifocal electroretinograms, optical coherence tomography and central visual sensitivity in advanced retinitis pigmentosa.Documenta ophthalmologica. Advances in ophthalmology · 2012Article
- The emerging role of stem cells in ocular neurodegeneration: hype or hope?Molecular and cellular biochemistry · 2012Review
- Ethical implications in the use of embryonic and adult neural stem cells.Stem cells international · 2012Article
- Stem cell therapy for retinal diseases: update.Stem cell research & therapy · 2011Review
- A comparison of stem cells for therapeutic use.Stem cell reviews and reports · 2011Review
- Promises of stem cell therapy for retinal degenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011Review
- Differential expression of neuronal genes in Müller glia in two- and three-dimensional cultures.Investigative ophthalmology & visual science · 2011Article
- Current concepts in the treatment of retinitis pigmentosa.Journal of ophthalmology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo describe the use of stem cells (SCs) for regeneration of retinal degenerations. Regenerative medicine intends to provide therapies for severe injuries or chronic diseases where endogenous repair does not sufficiently restore the tissue. Pluripotent SCs, with their capacity to give rise to specialized cells, are the most promising candidates for clinical application. Despite encouraging results, a combination with up-to-date tissue engineering might be critical for ultimate success.
designThe focus is on the use of SCs for regeneration of retinal degenerations. Cell populations include embryonic, neural, and bone marrow-derived SCs, and engineered grafts will also be described.
resultsExperimental approaches have successfully replaced damaged photoreceptors and retinal pigment epithelium using endogenous and exogenous SCs.
conclusionsStem cells have the potential to significantly impact retinal regeneration. A combination with bioengineering may bear even greater promise. However, ethical and scientific issues have yet to be solved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.