ArticleMolecular and cellular biology2009
Spatially restricted translation of the xCR1 mRNA in Xenopus embryos.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- TurboID functions as an efficient biotin ligase for BioID applications in Xenopus embryos.Developmental biology · 2022Article
- Bicaudal-C Post-transcriptional regulator of cell fates and functions.Frontiers in cell and developmental biology · 2022Review
- Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression inLife (Basel, Switzerland) · 2021Article
- A single KH domain in Bicaudal-C links mRNA binding and translational repression functions to maternal development.Development (Cambridge, England) · 2019Article
- Assaying NanoLuc Luciferase Activity from mRNA-Injected Xenopus Embryos.Methods in molecular biology (Clifton, N.J.) · 2019Article
- The translational regulation of maternal mRNAs in time and space.FEBS letters · 2018Review
- Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development.Advances in experimental medicine and biology · 2017Review
- A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators.Development (Cambridge, England) · 2016Article
- Keeping a lid on nodal: transcriptional and translational repression of nodal signalling.Open biology · 2016Review
- The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.Seminars in cancer biology · 2014Review
- Determinants of RNA binding and translational repression by the Bicaudal-C regulatory protein.The Journal of biological chemistry · 2014Article
- Bicaudal-C spatially controls translation of vertebrate maternal mRNAs.RNA (New York, N.Y.) · 2013Article
- Article
- Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells.PloS one · 2010Article
- Polyribosome analysis for investigating mRNA translation in Xenopus oocytes, eggs and embryos.Methods (San Diego, Calif.) · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The xCR1 protein is a maternal determinant and cofactor for nodal signaling in vertebrate embryos. The xCR1 protein accumulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed equally throughout all embryonic cells. Here, we show that vegetal cell-specific translational repression of xCR1 mRNA contributes to this spatially restricted accumulation of the xCR1 protein in Xenopus embryos. xCR1 mRNA was associated with polyribosomes in animal cells but not vegetal cells. A 351-nucleotide region of xCR1 mRNA's 3' untranslated region was sufficient to confer a spatially restricted pattern of translation to a luciferase reporter mRNA by repressing translation in vegetal cells. Repression depended upon the mRNA's 5' cap but not its 3' poly(A) tail. Furthermore, the region of xCR1 mRNA sufficient to confer vegetal cell-specific repression contained both Pumilio binding elements (PBEs) and binding sites for the CUG-BP1 protein. The PBEs and the CUG-BP1 sites were necessary but not sufficient for translation repression. Our studies of xCR1 mRNA document the first example of spatially regulated translation in controlling the asymmetric distribution of a maternal determinant in vertebrates.
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Registered trials
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