ReviewProceedings. Biological sciences2009
The role of natural environments in the evolution of resistance traits in pathogenic bacteria.
Review in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
170 citing papers in PubMed, 1 synthesis or guideline pooled it, 501 citations in OpenAlex.
- Pooled it
- Insights into the bioremediation potential of native Bacillus isolates and their consortia against Iron, Cadmium and Chromium at pH 5.0.Scientific reports · 2026Article
- Biofilm Formation and Plastic Degradation in Bacteria from Different Environments: Evidence for Phenotypic Acclimation and Metabolic Exaptation.Microorganisms · 2026Article
- Antimicrobial resistance within the one health lens: global drivers, mechanisms and public health policy gaps in low resource settings.Frontiers in cellular and infection microbiology · 2026Review
- Environmental resistomes and antimicrobial resistance: integrating the One Health framework.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- The diverse phenotypic and mutational landscape induced by fluoroquinolone treatment.mSystems · 2025Article
- Landscape of mobile genetic elements and their functional cargo across the gastrointestinal tract microbiomes in ruminants.Microbiome · 2025Article
- Antimicrobial Resistance and Wildlife: Occurrence of Antimicrobial Resistance Genes in Red Foxes (Animals : an open access journal from MDPI · 2025Article
- Biofilm Formation, Antibiotic Resistance, and Virulence Analysis of Human and Avian OriginVeterinary sciences · 2025Article
- Prevalence of ESBL-Resistant Genes in Birds in Italy-A Comprehensive Review.Animals : an open access journal from MDPI · 2025Review
- A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections.NPJ biofilms and microbiomes · 2025Review
- Plasmid Backbone Impacts Conjugation Rate, Transconjugant Fitness, and Community Assembly of Genetically Bioaugmented Soil Microbes for PAH Bioremediation.ACS environmental Au · 2025Article
- Charging and Aggregation of Nano-Clay Na-Montmorillonite in the Presence of Ciprofloxacin.Nanomaterials (Basel, Switzerland) · 2025Article
- Detection of Antibiotic-Resistance Genes in Drinking Water: A Study at a University in the Peruvian Amazon.International journal of environmental research and public health · 2025Article
- Deep-Sea Ecosystems as an Unexpected Source of Antibiotic Resistance Genes.Marine drugs · 2024Article
- Biofilm formation on microplastics and interactions with antibiotics, antibiotic resistance genes and pathogens in aquatic environment.Eco-Environment & Health · 2024Review
- Increased antibiotic resistance gene abundance linked to intensive bacterial competition in the phyllosphere across an elevational gradient.Environmental microbiology reports · 2024Article
- Antimicrobial Resistance in African Great Apes.Antibiotics (Basel, Switzerland) · 2024Review
- Review
- Investigating the resistome of haemolytic bacteria in Arctic soils.Environmental microbiology reports · 2024Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics are among the most valuable compounds used for fighting human diseases. Unfortunately, pathogenic bacteria have evolved towards resistance. One important and frequently forgotten aspect of antibiotics and their resistance genes is that they evolved in non-clinical (natural) environments before the use of antibiotics by humans. Given that the biosphere is mainly formed by micro-organisms, learning the functional role of antibiotics and their resistance elements in nature has relevant implications both for human health and from an ecological perspective. Recent works have suggested that some antibiotics may serve for signalling purposes at the low concentrations probably found in natural ecosystems, whereas some antibiotic resistance genes were originally selected in their hosts for metabolic purposes or for signal trafficking. However, the high concentrations of antibiotics released in specific habitats (for instance, clinical settings) as a consequence of human activity can shift those functional roles. The pollution of natural ecosystems by antibiotics and resistance genes might have consequences for the evolution of the microbiosphere. Whereas antibiotics produce transient and usually local challenges in microbial communities, antibiotic resistance genes present in gene-transfer units can spread in nature with consequences for human health and the evolution of environmental microbiota that are largely ignored.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.