ReviewBiochemistry2009
Porosome: the secretory portal in cells.
Review in Biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The old and the new about the contractile vacuole of Trypanosoma cruzi.The Journal of eukaryotic microbiology · 2022Review
- Platelet Membrane: An Outstanding Factor in Cancer Metastasis.Membranes · 2022Review
- Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23 leads to massive inhibition in exocytosis from mast cells.Journal of biosciences · 2018Article
- The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells.PLoS pathogens · 2016Article
- Discoveries Interview: Professor Bhanu P. Jena on the discovery of the porosome, the universal machinery for cellular secretion.Discoveries (Craiova, Romania) · 2014Article
- NeuronalJournal of molecular structure · 2014Article
- The protective effect of myo-inositol on hippocamal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus.Cellular and molecular neurobiology · 2013Article
- Multiple roles for the actin cytoskeleton during regulated exocytosis.Cellular and molecular life sciences : CMLS · 2013Review
- The SNARE complex in neuronal and sensory cells.Molecular and cellular neurosciences · 2012Review
- Mapping the zinc-transporting system in mammary cells: molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation.Journal of cellular physiology · 2012Article
- Compartmentalization of pancreatic secretory zymogen granules as revealed by low-voltage transmission electron microscopy.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Regulation of secretory granule size by the precise generation and fusion of unit granules.Journal of cellular and molecular medicine · 2010Review
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
Porosomes are supramolecular, cup-shaped lipoprotein structures at the cell plasma membrane, where membrane-bound secretory vesicles dock and fuse to release intravesicular contents to the outside during cell secretion. The porosome opening to the outside ranges from 150 nm in diameter in acinar cells of the exocrine pancreas to 12 nm in neurons. In the past decade, the composition of the porosome, its structure and dynamics at nanometer resolution in real time, and its functional reconstitution into an artificial lipid membrane have been described. Discovery of the universal secretory machinery in cells, the porosome, came as no surprise since porosome-like "canaliculi" structures for secretion from human platelets, the secretory machinery in single-cell organisms like the secretion apparatus in bacteria and Toxoplasma gondii, and the contractile vacuole in paramecium have been demonstrated. In this review, the discovery of the porosome complex and the molecular mechanism of its function and how this information provides a new understanding of cell secretion are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.