ReviewCellular and molecular neurobiology2009
Chemokines as possible targets in modulation of the secondary damage after acute spinal cord injury: a review.
Review in Cellular and molecular neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Engineered CCR2 positive macrophages coordinate immunoregulation with neural regeneration and matrix remodeling after spinal cord injury.Theranostics · 2026Article
- The Impact of Nuclear Factor Kappa B on the Response of Microglia in Spinal Cord Injuries.Cureus · 2025Review
- Spinal cord injury enhances lung inflammation and exacerbates immune response following exposure to LPS.Frontiers in immunology · 2024Article
- Serum CCL21 as a Potential Biomarker for Cognitive Impairment in Spinal Cord Injury.BioMed research international · 2020Article
- CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells.Aging · 2019Article
- Pectolinarigenin promotes functional recovery and inhibits apoptosis in rats following spinal cord injuries.Experimental and therapeutic medicine · 2019Article
- The non-psychoactive phytocannabinoid cannabidiol (CBD) attenuates pro-inflammatory mediators, T cell infiltration, and thermal sensitivity following spinal cord injury in mice.Cellular immunology · 2018Article
- Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?Neural regeneration research · 2018Article
- B-Cell Depletion with CD20 Antibodies as New Approach in the Treatment of Inflammatory and Immunological Events Associated with Spinal Cord Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Article
- Neuroprotective effects of sildenafil in experimental spinal cord injury in rabbits.Bosnian journal of basic medical sciences · 2015Article
- Neuroprotective effect of ginseng against spinal cord injury induced oxidative stress and inflammatory responses.International journal of clinical and experimental medicine · 2015Article
- Blocking neurogenic inflammation for the treatment of acute disorders of the central nervous system.International journal of inflammation · 2013Article
- Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury.Journal of neuroinflammation · 2012Article
- Inflammation & apoptosis in spinal cord injury.The Indian journal of medical research · 2012Review
- Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury.Journal of neurotrauma · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spite of many promising experimental studies, an effective treatment dramatically eliminating the secondary damage after spinal cord injury (SCI) is still missing. Since clinical data on the therapeutical effect after methylprednisolone treatment are not conclusive, new therapeutical modalities targeting specific components of secondary spinal cord damage needs to be developed. It is known that immune cells are recruited to injury sites by chemokines, which are small, structurally similar proteins released locally at the site of inflammation. Hence, this review was aimed to summarize possible roles of chemokines in the inflammation following SCI as well as to identify possible new therapeutical targets which can potentially be effective in ameliorating individual components of this inflammatory response. Data concerning inflammation reduction together with techniques improving axonal growth, cell replacement and remyelinization, may be crucial to move a small step forward in an attempt to make paraplegic and quadriplegic patients to walk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.