ArticleClinical orthopaedics and related research2009
Chondrocyte apoptosis after simulated intraarticular fracture: a comparison of histologic detection methods.
Article in Clinical orthopaedics and related research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- [Posterior open approach combined with suture bridge technique for tibial insertion avulsion fractures of posterior cruciate ligament].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Influence of articular incongruency on coronal alignment after surgical fixation of lateral tibial plateau fractures.BMC musculoskeletal disorders · 2025Article
- Fixation augmentation using calcium-phosphate bone substitute improves outcomes of complex tibial plateau fractures. A matched, cohort study.International orthopaedics · 2018Article
- Balloon tibioplasty for reduction of depressed tibial plateau fractures: Preliminary radiographic and clinical results.International orthopaedics · 2016Article
- Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis.Arthritis research & therapy · 2016Article
- Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis.International journal of molecular sciences · 2015Review
- Inflation osteoplasty: in vitro evaluation of a new technique for reducing depressed intra-articular fractures of the tibial plateau and distal radius.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2012Article
- Cryopreservation increases apoptosis in human menisci.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Article
- TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Joint aging and chondrocyte cell death.International journal of clinical rheumatology · 2010Article
- Effect of hyaluronic acid on chondrocyte apoptosis.Acta ortopedica brasileiraArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate evaluation of programmed cell death, or apoptosis, in chondrocytes is essential to studying cartilage injury. We evaluated four methods of detecting chondrocyte-programmed cell death in formalin-fixed, paraffin-embedded cartilage after experimental osteochondral fracture. Human osteochondral explants were subjected to experimental fracture in a manner known to induce high levels of chondrocyte-programmed cell death. After 4 days in culture, specimens were fixed and analyzed for programmed cell death using: (1) terminal deoxynucleotidyl transferase end labeling; (2) DNA denaturation analysis using an antibody specific for single-stranded DNA; (3) immunohistochemistry using antisera specific for active caspase-3; and (4) in situ oligonucleotide ligation. Quantitative analysis of programmed cell death levels for each technique was performed comparing injured and uninjured areas of cartilage. We observed differences between injured and uninjured areas of cartilage using the four methods. Human cartilage fixed in zinc-formalin and embedded in paraffin is amenable to programmed cell death analysis using any of four independent methods, each of which ostensibly has some advantages in terms of assaying different steps along the apoptotic pathway. Using the protocols described in this article, investigators may have additional tools to identify and quantify chondrocytes undergoing programmed cell death after experimental cartilage injury.
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