ArticleBone marrow transplantation2009
Low bone mineral density is associated with insulin resistance in bone marrow transplant subjects.
Article in Bone marrow transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Bone loss and vitamin D deficiency in children undergoing hematopoietic cell transplantation.Pediatric blood & cancer · 2015Trial
- Centrally located body fat is associated with lower bone mineral density in older Puerto Rican adults.The American journal of clinical nutrition · 2011Trial
- Relationship between the High Fatty Liver Index and Risk of Fracture.Gut and liver · 2023Article
- Longitudinal associations of insulin resistance with change in bone mineral density in midlife women.JCI insight · 2022Article
- Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review.International journal of molecular sciences · 2021Review
- Increasing fasting glucose and fasting insulin associated with elevated bone mineral density-evidence from cross-sectional and MR studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- To D or not to D: vitamin D in hematopoietic cell transplantation.Bone marrow transplantation · 2020Review
- Factors influencing the late phase of recovery after bone mineral density loss in allogeneic stem cell transplantation survivors.Bone marrow transplantation · 2016Article
- Association of nonalcoholic fatty liver disease with bone mineral density and serum osteocalcin levels in Korean men.European journal of gastroenterology & hepatology · 2016Article
- Association of lipid parameters and insulin resistance with bone health in South Korean adolescents.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Nonalcoholic fatty liver disease and decreased bone mineral density: is there a link?Journal of endocrinological investigation · 2015Review
- Insulin resistance and bone strength: findings from the study of midlife in the United States.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Endocrine complications after busulphan and cyclophosphamide based hematopoietic stem cell transplant: A single tertiary care centre experience.Indian journal of endocrinology and metabolism · 2013Article
- Low bone mineral density in chinese adults with nonalcoholic Fatty liver disease.International journal of endocrinology · 2013Article
- Decreased bone mineral density in young adults treated with SCT in childhood: the role of 25-hydroxyvitamin D.Bone marrow transplantation · 2012Article
- Osteoporosis after transplantation.Current osteoporosis reports · 2012Review
- [Not Available].Revista brasileira de hematologia e hemoterapiaArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-BMT subjects have an increased bone fracture risk. Additionally, several factors were associated with osteopenia and osteoporosis in these individuals. We aimed to identify other factors associated with osteopenia and osteoporosis in allogeneic post-BMT subjects. We conducted a cross-sectional study with 47 allogeneic post- BMT subjects. Serum 25-hydroxyvitamin D (25(OH)D), parathyroid hormone, ferritin, vitamin B(12), insulin, glucose, cholesterol and triglyceride levels were measured. Insulin resistance and secretion were estimated through the homeostatic model assessment for insulin resistance (HOMA-IR) and homeostatic model assessment for beta-cell function (HOMA-B), respectively. A bone densitometry (BMD) was also obtained. The median time after BMT was 47.7 (12-115) months. Osteoporosis was identified in 17.0% of the subjects and osteopenia in 19.7%. The mean serum ferritin (P=0.002), insulin (P<0.0001), glucose (P=0.003) and triglyceride (P=0.018) levels were higher in individuals with osteopenia/osteoporosis. HOMA-IR (P<0.0001) and HOMA-B (P<0.0001) were increased in post-BMT subjects with osteopenia/osteoporosis. There was no other factor associated with the outcome. After adjustments ferritin, serum 25(OH)D and HOMA-IR remained independently associated with osteopenia/osteoporosis; however triglycerides no longer were. In conclusion, in the present study, low serum 25(OH)D levels, high serum ferritin levels and insulin resistance were associated with osteopenia/osteoporosis in post-BMT subjects.
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