ArticleNature neuroscience2009
BK channels modulate pre- and postsynaptic signaling at reciprocal synapses in retina.
Article in Nature neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.Nature genetics · 2018Pooled it
- IK Channel Confers Fine-tuning of Rod Bipolar Cell Excitation and Synaptic Transmission in the Retina.Function (Oxford, England) · 2025Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- The Variety of Mechanosensitive Ion Channels in Retinal Neurons.International journal of molecular sciences · 2024Review
- The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease.International journal of molecular sciences · 2024Review
- Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024Review
- Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models.The Journal of general physiology · 2023Article
- CaInternational journal of molecular sciences · 2023Review
- Calcium Channels in Retinal Function and Disease.Annual review of vision science · 2022Review
- Large-conductance calcium-activated potassium channel haploinsufficiency leads to sensory deficits in the visual system: a case report.Journal of medical case reports · 2022Article
- Dendritic Morphology of an Inhibitory Retinal Interneuron Enables Simultaneous Local and Global Synaptic Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABAThe European journal of neuroscience · 2022Article
- Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling.Current biology : CB · 2022Article
- Two Functional Classes of Rod Bipolar Cells in the Healthy and Degenerated Optogenetically Treated Murine Retina.Frontiers in cellular neuroscience · 2021Article
- PTEN Expression Regulates Gap Junction Connectivity in the Retina.Frontiers in neuroanatomy · 2021Article
- Article
- A17 Amacrine Cells and Olfactory Granule Cells: Parallel Processors of Early Sensory Information.Frontiers in cellular neuroscience · 2020Review
- Review
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In the mammalian retina, A17 amacrine cells provide reciprocal inhibitory feedback to rod bipolar cells, thereby shaping the time course of visual signaling in vivo. Previous results have indicated that A17 feedback can be triggered by Ca(2+) influx through Ca(2+)-permeable AMPA receptors and can occur independently of voltage-gated Ca(2+) (Ca(v)) channels, whose presence and functional role in A17 dendrites have not yet been explored. We combined electrophysiology, calcium imaging and immunohistochemistry and found that L-type Ca(v) channels in rat A17 amacrine cells were located at the sites of reciprocal synaptic feedback and that their contribution to GABA release was diminished by large-conductance Ca(2+)-activated potassium (BK) channels, which suppress postsynaptic depolarization in A17s and limit Ca(v) channel activation. We also found that BK channels, by limiting GABA release from A17s, regulate the flow of excitatory synaptic transmission through the rod pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.