ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Active stiffening of mitral valve leaflets in the beating heart.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Human and Porcine Marginal Chordal Forces in a Vacuum Based Physiological In Vitro Mitral Valve Model.Cardiovascular engineering and technology · 2026Article
- Inertia-Driven Mitral and Aortic Valves: The Isovolumic Myth.Medical research archives · 2025Article
- Tricuspid valve leaflet remodeling in sheep with biventricular heart failure: A comparison between leaflets.Acta biomaterialia · 2025Article
- Three-dimensional printing in modelling mitral valve interventions.Echo research and practice · 2023Review
- Patient-Specific Inverse Modeling of In Vivo Cardiovascular Mechanics with Medical Image-Derived Kinematics as Input Data: Concepts, Methods, and Applications.Applied sciences (Basel, Switzerland) · 2022Article
- Complex sympathetic regulation in adolescent mitral valve prolapse.Physiological research · 2021Article
- Serotonin and catecholamines in the development and progression of heart valve diseases.Cardiovascular research · 2017Article
- Mitral valve disease--morphology and mechanisms.Nature reviews. Cardiology · 2015Review
- Computational modeling of cardiac valve function and intervention.Annual review of biomedical engineering · 2014Review
- Mechanics of the mitral valve: a critical review, an in vivo parameter identification, and the effect of prestrain.Biomechanics and modeling in mechanobiology · 2013Review
- Computational modeling of chemo-electro-mechanical coupling: a novel implicit monolithic finite element approach.International journal for numerical methods in biomedical engineering · 2013Article
- On the effect of prestrain and residual stress in thin biological membranes.Journal of the mechanics and physics of solids · 2013Article
- The clinical anatomy and pathology of the human atrioventricular valves: implications for repair or replacement.Journal of cardiovascular translational research · 2013Review
- A fully implicit finite element method for bidomain models of cardiac electromechanics.Computer methods in applied mechanics and engineering · 2013Article
- Vagal nerve stimulation reduces anterior mitral valve leaflet stiffness in the beating ovine heart.Journal of biomechanics · 2012Article
- On the in vivo deformation of the mitral valve anterior leaflet: effects of annular geometry and referential configuration.Annals of biomedical engineering · 2012Article
- Frontiers in growth and remodeling.Mechanics research communications · 2012Article
- Mitral valve annuloplasty: a quantitative clinical and mechanical comparison of different annuloplasty devices.Annals of biomedical engineering · 2012Article
- Computational modeling of growth: systemic and pulmonary hypertension in the heart.Biomechanics and modeling in mechanobiology · 2011Article
- Rigid, complete annuloplasty rings increase anterior mitral leaflet strains in the normal beating ovine heart.Circulation · 2011Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The anterior leaflet of the mitral valve (MV), viewed traditionally as a passive membrane, is shown to be a highly active structure in the beating heart. Two types of leaflet contractile activity are demonstrated: 1) a brief twitch at the beginning of each beat (reflecting contraction of myocytes in the leaflet in communication with and excited by left atrial muscle) that is relaxed by midsystole and whose contractile activity is eliminated with beta-receptor blockade and 2) sustained tone during isovolumic relaxation, insensitive to beta-blockade, but doubled by stimulation of the neurally rich region of aortic-mitral continuity. These findings raise the possibility that these leaflets are neurally controlled tissues, with potentially adaptive capabilities to meet the changing physiological demands on the heart. They also provide a basis for a permanent paradigm shift from one viewing the leaflets as passive flaps to one viewing them as active tissues whose complex function and dysfunction must be taken into account when considering not only therapeutic approaches to MV disease, but even the definitions of MV disease itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.