ArticleGenetics2009
Genetic architecture of tameness in a rat model of animal domestication.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight From a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model.Biological psychiatry · 2021Pooled it
- Selection for Tameness in Red Junglefowl Recapitulates Genetic Loci Associated With Domestication-Related Brain Composition.Molecular ecology · 2025Article
- Welfare of American mink, red and Arctic foxes, raccoon dog and chinchilla kept for fur production.EFSA journal. European Food Safety Authority · 2025Article
- Scleral appearance is not a correlate of domestication in mammals.Zoological letters · 2023Article
- Article
- Domestication of farmed fishFrontiers in endocrinology · 2022Review
- Article
- From the Eurasian Steppes to the Roman Circuses: A Review of Early Development of Horse Breeding and Management.Animals : an open access journal from MDPI · 2021Review
- Tameness correlates with domestication related traits in a Red Junglefowl intercross.Genes, brain, and behavior · 2021Article
- Combined change of behavioral traits for domestication and gene-networks in mice selectively bred for active tameness.Genes, brain, and behavior · 2021Article
- Age-Related Changes in the Behaviour of Domestic Horses as Reported by Owners.Animals : an open access journal from MDPI · 2020Article
- Disruptive natural selection by male reproductive potential prevents underexpression of protein-coding genes on the human Y chromosome as a self-domestication syndrome.BMC genetics · 2020Article
- Omics Application in Animal Science-A Special Emphasis on Stress Response and Damaging Behaviour in Pigs.Genes · 2020Review
- Selection for reduced fear in red junglefowl changes brain composition and affects fear memory.Royal Society open science · 2020Article
- Morphology does not covary with predicted behavioral correlations of the domestication syndrome in dogs.Evolution letters · 2020Article
- Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry.Translational psychiatry · 2020Article
- Effect of isolation on coat colour polymorphism of Polynesian rats in Island Southeast Asia and the Pacific.PeerJ · 2019Article
- Revisiting the famous farm foxes: A psychological perspective.Learning & behavior · 2018Article
- Measuring Active and Passive Tameness Separately in Mice.Journal of visualized experiments : JoVE · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A common feature of domestic animals is tameness-i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.