ArticleGenetics2009
Novel nucleotide sequence motifs that produce hotspots of meiotic recombination in Schizosaccharomyces pombe.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Measuring Meiotic Recombination Frequency in Schizosaccharomyces pombe Using an Engineered Genetic Interval.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Creating Meiotic Recombination-Regulating DNA Sites byBiomolecules · 2024Article
- Distance-dependent effects on CRISPR/Cas9-mediated genome editing inmicroPublication biology · 2024Article
- Regulation Mechanisms of Meiotic Recombination Revealed from the Analysis of a Fission Yeast Recombination HotspotBiomolecules · 2022Review
- Facultative heterochromatin formation in rDNA is essential for cell survival during nutritional starvation.Nucleic acids research · 2022Article
- Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination.Genetics · 2022Article
- Redirecting meiotic DNA break hotspot determinant proteins alters localized spatial control of DNA break formation and repair.Nucleic acids research · 2022Article
- Adaptive Control of the Meiotic Recombination Landscape by DNA Site-dependent Hotspots With Implications for Evolution.Frontiers in genetics · 2022Article
- lncRNA transcription induces meiotic recombination through chromatin remodelling in fission yeast.Communications biology · 2021Article
- Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast.G3 (Bethesda, Md.) · 2019Article
- Diverse DNA Sequence Motifs Activate Meiotic Recombination Hotspots Through a Common Chromatin Remodeling Pathway.Genetics · 2019Article
- Divergent Fine-Scale Recombination Landscapes between a Freshwater and Marine Population of Threespine Stickleback Fish.Genome biology and evolution · 2019Article
- Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot.Epigenetics & chromatin · 2018Article
- Sequence requirement of the ade6-4095 meiotic recombination hotspot in Schizosaccharomyces pombe.Genetica · 2018Article
- Article
- Complexity of genetic mechanisms conferring nonuniformity of recombination in maize.Scientific reports · 2017Article
- Recombination rate variation in mice from an isolated island.Molecular ecology · 2017Article
- Predictive Models of Recombination Rate Variation across the Drosophila melanogaster Genome.Genome biology and evolution · 2016Article
- Meiotic DSB patterning: A multifaceted process.Cell cycle (Georgetown, Tex.) · 2016Review
- Article
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Authors and funding
4 authors.
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Abstract
In many organisms, including yeasts and humans, meiotic recombination is initiated preferentially at a limited number of sites in the genome referred to as recombination hotspots. Predicting precisely the location of most hotspots has remained elusive. In this study, we tested the hypothesis that hotspots can result from multiple different sequence motifs. We devised a method to rapidly screen many short random oligonucleotide sequences for hotspot activity in the fission yeast Schizosaccharomyces pombe and produced a library of approximately 500 unique 15- and 30-bp sequences containing hotspots. The frequency of hotspots found suggests that there may be a relatively large number of different sequence motifs that produce hotspots. Within our sequence library, we found many shorter 6- to 10-bp motifs that occurred multiple times, many of which produced hotspots when reconstructed in vivo. On the basis of sequence similarity, we were able to group those hotspots into five different sequence families. At least one of the novel hotspots we found appears to be a target for a transcription factor, as it requires that factor for its hotspot activity. We propose that many hotspots in S. pombe, and perhaps other organisms, result from simple sequence motifs, some of which are identified here.
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