ArticleJournal of bacteriology2009
Inhibition of selenium metabolism in the oral pathogen Treponema denticola.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Microbial signatures in human periodontal disease: a metatranscriptome meta-analysis.Frontiers in microbiology · 2024Pooled it
- Inhibition of selenoprotein synthesis is not the mechanism by which auranofin inhibits growth of Clostridioides difficile.Scientific reports · 2023Article
- Review
- Gold complex compounds that inhibit drug-resistantFrontiers in antibiotics · 2023Article
- Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation.Molecules (Basel, Switzerland) · 2022Article
- Strategies for the Improvement of Metal-Based Chemotherapeutic Treatments.Biomedicines · 2021Review
- In Vitro Investigation of Auranofin as a Treatment for Clostridium difficile Infection.Drugs in R&D · 2020Article
- Synthesis and Structure-Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens.Journal of medicinal chemistry · 2019Article
- Article
- Better living through chemistry: Addressing emerging antibiotic resistance.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- The effects of phosphanegold(I) thiolates on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype.Journal of negative results in biomedicine · 2017Article
- Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens.Scientific reports · 2016Article
- Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin.Future medicinal chemistry · 2016Article
- Auranofin: repurposing an old drug for a golden new age.Drugs in R&D · 2015Article
- Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains.Journal of inorganic biochemistry · 2014Article
- Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses.PLoS pathogens · 2014Article
- The biological activity of auranofin: implications for novel treatment of diseases.Inflammopharmacology · 2012Review
- The riboswitch regulates a thiamine pyrophosphate ABC transporter of the oral spirochete Treponema denticola.Journal of bacteriology · 2011Article
- A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production.Journal of bacteriology · 2011Article
- Targeting selenium metabolism and selenoproteins: novel avenues for drug discovery.Metallomics : integrated biometal science · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this report we provide evidence that the antimicrobial action of stannous salts and a gold drug, auranofin, against Treponema denticola is mediated through inhibition of the metabolism of selenium for synthesis of selenoproteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.