ArticlePlant physiology2009
Arabidopsis chloroplastic glutathione peroxidases play a role in cross talk between photooxidative stress and immune responses.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 189 citations in OpenAlex.
- The family of glutathione peroxidase proteins and their role against biotic stress in plants: a systematic review.Frontiers in plant science · 2025Pooled it
- Adaptive response to long-term high temperatures during the reproductive development in Arabidopsis thaliana.Planta · 2026Article
- Membrane stability under heat stress: molecular signaling, lipid remodeling, and defense mechanisms in plants.Plant cell reports · 2026Review
- Comprehensive identification of glutathione peroxidase (GPX) gene family and effect of GhGPX4 on reactive oxygen species metabolism in cotton.Frontiers in plant science · 2026Article
- Biochar application alleviates drought-induced oxidative stress by activating the salicylic acid-mediated glutathione synthesis pathway in Brassica napus.BMC plant biology · 2025Article
- The Glutathione Peroxidase Gene Family inAntioxidants (Basel, Switzerland) · 2025Article
- Beware of Sealing Film of Petri Dishes!-Alters the Expression of a Large Number of Genes.International journal of molecular sciences · 2025Article
- Transcriptome Analysis Revealed Hub Genes Related to Tipburn Resistance in Chinese Cabbage (Plants (Basel, Switzerland) · 2025Article
- Transgenerational Plasticity Enhances the Tolerance of Duckweed (International journal of molecular sciences · 2024Article
- Article
- Biochemical and Functional Profiling of Thioredoxin-Dependent Cytosolic GPX-like Proteins inBiomolecules · 2024Article
- Effects of Low-Fish-Meal Diet Supplemented with Coenzyme Q10 on Growth Performance, Antioxidant Capacity, Intestinal Morphology, Immunity and Hypoxic Resistance ofAntioxidants (Basel, Switzerland) · 2023Article
- Genome-Wide Analysis and Expression Profiling of the Glutathione Peroxidase-like Enzyme Gene Family inInternational journal of molecular sciences · 2023Article
- The Glutathione Peroxidase Gene Family inGenes · 2023Article
- Photosystems under high light stress: throwing light on mechanism and adaptation.Photosynthetica · 2023Review
- Plasticity of Arabidopsis rosette transcriptomes and photosynthetic responses in dynamic light conditions.Plant direct · 2023Article
- Review
- Proteomic Analysis of Apple Response toJournal of fungi (Basel, Switzerland) · 2022Article
- Plant Glutathione Peroxidases: Non-Heme Peroxidases with Large Functional Flexibility as a Core Component of ROS-Processing Mechanisms and Signalling.Antioxidants (Basel, Switzerland) · 2022Review
- Salicylic Acid, a Multifaceted Hormone, Combats Abiotic Stresses in Plants.Life (Basel, Switzerland) · 2022Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Glutathione peroxidases (GPXs; EC 1.11.1.9) are key enzymes of the antioxidant network in plants and animals. In order to investigate the role of antioxidant systems in plant chloroplasts, we generated Arabidopsis (Arabidopsis thaliana) transgenic lines that are depleted specifically in chloroplastic (cp) forms of GPX1 and GPX7. We show that reduced cpGPX expression, either in transgenic lines with lower total cpGPX expression (GPX1 and GPX7) or in a gpx7 insertion mutant, leads to compromised photooxidative stress tolerance but increased basal resistance to virulent bacteria. Depletion of both GPX1 and GPX7 expression also caused alterations in leaf cell and chloroplast morphology. Leaf tissues were characterized by shorter and more rounded palisade cells, irregular spongy mesophyll cells, and larger intercellular air spaces compared with the wild type. Chloroplasts had larger and more abundant starch grains than in wild-type and gpx7 mutant plants. Constitutively reduced cpGPX expression also led to higher foliar ascorbic acid, glutathione, and salicylic acid levels in plants exposed to higher light intensities. Our results suggest partially overlapping functions of GPX1 and GPX7. The data further point to specific changes in the chloroplast ascorbate-glutathione cycle due to reduced cpGPX expression, initiating reactive oxygen species and salicylic acid pathways that affect leaf development, light acclimation, basal defense, and cell death programs. Thus, cpGPXs regulate cellular photooxidative tolerance and immune responses.
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