ArticlePlant physiology2009
Mitochondrial and nuclear localization of a novel pea thioredoxin: identification of its mitochondrial target proteins.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 95 citations in OpenAlex.
- Linking redox and calcium signaling via thioredoxins.Journal of experimental botany · 2026Review
- New role for thioredoxins in plants: Implication of TRXo1 in protein depersulfidation.Redox biology · 2025Article
- Antioxidant Responses and Redox Regulation Within Plant-Beneficial Microbe Interaction.Antioxidants (Basel, Switzerland) · 2024Review
- Redox regulation, thioredoxins, and glutaredoxins in retrograde signalling and gene transcription.Journal of experimental botany · 2023Review
- Thioredoxin TRXo1 is involved in ABA perception via PYR1 redox regulation.Redox biology · 2023Article
- Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging.Antioxidants (Basel, Switzerland) · 2022Review
- How to Cope with the Challenges of Environmental Stresses in the Era of Global Climate Change: An Update on ROS Stave off in Plants.International journal of molecular sciences · 2022Review
- Autophagy Is Involved in the Viability of Overexpressing ThioredoxinAntioxidants (Basel, Switzerland) · 2021Article
- Mitochondrial redox systems as central hubs in plant metabolism and signaling.Plant physiology · 2021Review
- ThioredoxinAntioxidants (Basel, Switzerland) · 2021Article
- Decreased Levels of ThioredoxinInternational journal of molecular sciences · 2021Article
- Genome communication in plants mediated by organelle-n-ucleus-located proteins.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Effects of Salicylic Acid on the Metabolism of Mitochondrial Reactive Oxygen Species in Plants.Biomolecules · 2020Review
- Redox-mediated kick-start of mitochondrial energy metabolism drives resource-efficient seed germination.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Thioredoxin Network in Plant Mitochondria: Cysteine S-Posttranslational Modifications and Stress Conditions.Frontiers in plant science · 2020Review
- Beyond Ethylene: New Insights Regarding the Role of Alternative Oxidase in the Respiratory Climacteric.Frontiers in plant science · 2020Review
- Assessment of Subcellular ROS and NO Metabolism in Higher Plants: Multifunctional Signaling Molecules.Antioxidants (Basel, Switzerland) · 2019Review
- On the role of the plant mitochondrial thioredoxin system during abiotic stress.Plant signaling & behavior · 2019Article
- Thioredoxin o-mediated reduction of mitochondrial alternative oxidase in the thermogenic skunk cabbage Symplocarpus renifolius.Journal of biochemistry · 2019Article
- MitochondrialAntioxidants (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants contain several genes encoding thioredoxins (Trxs), small proteins involved in the regulation of the activity of many enzymes through dithiol-disulfide exchange. In addition to chloroplastic and cytoplasmic Trx systems, plant mitochondria contain a reduced nicotinamide adenine dinucleotide phosphate-dependent Trx reductase and a specific Trx o, and to date, there have been no reports of a gene encoding a plant nuclear Trx. We report here the presence in pea (Pisum sativum) mitochondria and nuclei of a Trx isoform (PsTrxo1) that seems to belong to the Trx o group, although it differs from this Trx type by its absence of introns in the genomic sequence. Western-blot analysis with isolated mitochondria and nuclei, immunogold labeling, and green fluorescent protein fusion constructs all indicated that PsTrxo1 is present in both cell compartments. Moreover, the identification by tandem mass spectrometry of the native mitochondrial Trx after gel filtration using the fast-protein liquid chromatography system of highly purified mitochondria and the in vitro uptake assay into isolated mitochondria also corroborated a mitochondrial location for this protein. The recombinant PsTrxo1 protein has been shown to be reduced more effectively by the Saccharomyces cerevisiae mitochondrial Trx reductase Trr2 than by the wheat (Triticum aestivum) cytoplasmic reduced nicotinamide adenine dinucleotide phosphate-dependent Trx reductase. PsTrxo1 was able to activate alternative oxidase, and it was shown to interact with a number of mitochondrial proteins, including peroxiredoxin and enzymes mainly involved in the photorespiratory process.
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