ArticleThe Journal of biological chemistry2009
LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 60 citations in OpenAlex.
- NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress.Science advances · 2025Article
- A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection.Mucosal immunology · 2024Article
- MiR-615 Agomir Encapsulated in Pluronic F-127 Alleviates Neuron Damage and Facilitates Function Recovery After Brachial Plexus Avulsion.Journal of molecular neuroscience : MN · 2022Article
- MiR-615 Regulates NSC Differentiation In Vitro and Contributes to Spinal Cord Injury Repair by Targeting LINGO-1.Molecular neurobiology · 2020Article
- Revealing PAK2's Function in the Cell Division through MKLP1's Interactome.BioMed research international · 2020Article
- Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats.Neuronal signaling · 2018Article
- Rab10 Disruption Results in Delayed OPC Maturation.Cellular and molecular neurobiology · 2017Article
- MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation.Neurochemical research · 2017Article
- Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells.PloS one · 2017Article
- Downregulation of ACSM3 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma.American journal of cancer research · 2017Article
- Genetic variants in Nogo receptor signaling pathways may be associated with early life adversity in schizophrenia susceptibility.BBA clinical · 2015Article
- LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.The Journal of biological chemistry · 2015Article
- Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling.British journal of pharmacology · 2015Article
- Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.Investigative ophthalmology & visual science · 2014Article
- Myocilin is involved in NgR1/Lingo-1-mediated oligodendrocyte differentiation and myelination of the optic nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration.Molecular cancer · 2014Article
- Novel implications of Lingo-1 and its signaling partners in schizophrenia.Translational psychiatry · 2014Article
- Axon growth inhibition by RhoA/ROCK in the central nervous system.Frontiers in neuroscience · 2014Review
- Experimental validation of 5 in-silico predicted glioma biomarkers.Neuro-oncology · 2013Article
- Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition.The European journal of neuroscience · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LINGO-1 is a component of the tripartite receptor complexes, which act as a convergent mediator of the intracellular signaling in response to myelin-associated inhibitors and lead to collapse of growth cone and inhibition of neurite extension. Although the function of LINGO-1 has been intensively studied, its downstream signaling remains elusive. In the present study, a novel interaction between LINGO-1 and a serine-threonine kinase WNK1 was identified by yeast two-hybrid screen. The interaction was further validated by fluorescence resonance energy transfer and co-immunoprecipitation, and this interaction was intensified by Nogo66 treatment. Morphological evidences showed that WNK1 and LINGO-1 were co-localized in cortical neurons. Furthermore, either suppressing WNK1 expression by RNA interference or overexpression of WNK1-(123-510) attenuated Nogo66-induced inhibition of neurite extension and inhibited the activation of RhoA. Moreover, WNK1 was identified to interact with Rho-GDI1, and this interaction was attenuated by Nogo66 treatment, further indicating its regulatory effect on RhoA activation. Taken together, our results suggest that WNK1 is a novel signaling molecule involved in regulation of LINGO-1 mediated inhibition of neurite extension.
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