ReviewCurrent opinion in immunology2009
Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.
Review in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
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- Genome-Wide Population Structure and Selection Signatures of Yunling Goat Based on RAD-seq.Animals : an open access journal from MDPI · 2022Article
- Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer-Autonomous DNA-Sensing Signaling Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase.Communications biology · 2022Article
- Molecular Identification ofFrontiers in immunology · 2022Article
- Systematic Approach to Find the Global Minimum of Relaxation Dispersion Data for Protein-Induced B-Z Transition of DNA.International journal of molecular sciences · 2021Article
- Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes.JCI insight · 2020Article
- Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy.International journal of molecular sciences · 2020Review
- Insights into the Synthesis, Secretion and Curing of Barnacle Cyprid Adhesive via Transcriptomic and Proteomic Analyses of the Cement Gland.Marine drugs · 2020Article
- Grass Carp (Frontiers in immunology · 2020Article
- Comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease.Immunobiology · 2019Article
- Thermodynamic Model for B-Z Transition of DNA Induced by Z-DNA Binding Proteins.Molecules (Basel, Switzerland) · 2018Review
- Comparative analysis of microbial sensing molecules in mucosal tissues with aging.Immunobiology · 2018Article
- Transcriptional profile in afferent lymph cells following vaccination with liposomes incorporating CpG.Immunology · 2015Article
- Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88.Journal of virology · 2015Article
- RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.Journal of virology · 2014Article
- Characterisation of cytoplasmic DNA complementary to non-retroviral RNA viruses in human cells.Scientific reports · 2014Article
- RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma.Cancer research · 2014Article
- Heme on innate immunity and inflammation.Frontiers in pharmacology · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sensing of nucleic acids by pattern recognition receptors is a central feature of innate immunity and is mediated by two types of receptors, Toll-like receptors and cytosolic receptors. Indeed, DNA, be it pathogen-derived or self-derived, can potently trigger the innate immune system; and much attention has been focused on the regulation of the DNA-sensing system(s) in the context of protective and pathological immune responses. An accumulating body of evidence has demonstrated that in addition to the membrane-bound type DNA-sensing receptor TLR9, there are cytosolic DNA receptors that can also evoke these responses. In particular, DAI (DLM-1/ZBP1), Trex1, and other regulators of the cytosolic DNA-sensing system have recently been identified and characterized. Here, we summarize our current understanding of how cytosolic DNA receptors contribute to the regulation of innate immune responses and discuss the complexity of the cytosolic DNA-sensing system as well as its future prospects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.