ArticleMethods in enzymology2009
Structural enzymology of polyketide synthases.
Article in Methods in enzymology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- NewTheScientificWorldJournal · 2025Pooled it
- Domain swapping of the C-terminal helix promotes the dimerization of a novel ribonuclease protein from Mycobacterium tuberculosis.Protein science : a publication of the Protein Society · 2023Article
- Construction of Bi-Enzyme Self-Assembly Clusters Based on SpyCatcher/SpyTag for the Efficient Biosynthesis of (R)-Ethyl 2-hydroxy-4-phenylbutyrate.Biomolecules · 2023Article
- Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior.Frontiers in genetics · 2021Review
- Structural and functional comparison of Saccharomonospora azurea strains in terms of primycin producing ability.World journal of microbiology & biotechnology · 2020Article
- Unique features of the ketosynthase domain in a nonribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.The Journal of biological chemistry · 2020Article
- An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase.Journal of the American Chemical Society · 2018Article
- Enzyme That Makes You Cry-Crystal Structure of Lachrymatory Factor Synthase from Allium cepa.ACS chemical biology · 2017Article
- One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis.Organic letters · 2017Article
- Limitations of the 'ambush hypothesis' at the single-gene scale: what codon biases are to blame?Molecular genetics and genomics : MGG · 2015Article
- Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer.BMC microbiology · 2014Article
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- Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling α-substituent stereochemistry.ACS chemical biology · 2013Article
- Dissecting complex polyketide biosynthesis.Computational and structural biotechnology journal · 2012Review
- The surfactant of Legionella pneumophila Is secreted in a TolC-dependent manner and is antagonistic toward other Legionella species.Journal of bacteriology · 2011Article
- Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway.Biochemistry · 2011Article
- Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein.ACS chemical biology · 2011Article
- SBSPKS: structure based sequence analysis of polyketide synthases.Nucleic acids research · 2010Article
- Cyclization of aromatic polyketides from bacteria and fungi.Natural product reports · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This chapter describes structural and associated enzymological studies of polyketide synthases, including isolated single domains and multidomain fragments. The sequence-structure-function relationship of polyketide biosynthesis, compared with homologous fatty acid synthesis, is discussed in detail. Structural enzymology sheds light on sequence and structural motifs that are important for the precise timing, substrate recognition, enzyme catalysis, and protein-protein interactions leading to the extraordinary structural diversity of naturally occurring polyketides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.