ArticleAutonomic neuroscience : basic & clinical2009
Brain Fos expression induced by the chemotherapy agent cisplatin in the rat is partially dependent on an intact abdominal vagus.
Article in Autonomic neuroscience : basic & clinical, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Intraperitoneal Injection of Cisplatin Induces Nausea-Like Responses without Vomiting in Chicks (The journal of poultry science · 2026Article
- Food and medicine homology: a potential nutritional intervention strategy for post-acute COVID-19 syndrome.Frontiers in pharmacology · 2025Review
- Olanzapine Administration Reduces Chemotherapy-Induced Nausea Behavior in Rats.Biological research for nursing · 2021Article
- Article
- Isoflurane induces c-Fos expression in the area postrema of the rat.Journal of anesthesia · 2019Article
- Possible involvement of central oxytocin in cisplatin-induced anorexia in rats.The journal of physiological sciences : JPS · 2018Article
- Chemotherapy-Induced Pica in Rats Reduced by Electroacupuncture.Neuromodulation : journal of the International Neuromodulation Society · 2018Review
- Excitatory Hindbrain-Forebrain Communication Is Required for Cisplatin-Induced Anorexia and Weight Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Role of the abdominal vagus and hindbrain in inhalational anesthesia-induced vomiting.Autonomic neuroscience : basic & clinical · 2017Article
- Effect of Pregnancy on Vocal Cord Histology: An Animal Experiment.Balkan medical journal · 2016Article
- Glutamate Receptors in the Central Nucleus of the Amygdala Mediate Cisplatin-Induced Malaise and Energy Balance Dysregulation through Direct Hindbrain Projections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting.European journal of pharmacology · 2014Review
- The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide.Neuropharmacology · 2012Article
- Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Motion sickness, nausea and thermoregulation: The "toxic" hypothesis.Temperature (Austin, Tex.)Review
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1 author at 1 institution in 1 country.
Funding
Abstract
Anticancer agents such as cisplatin stimulate nausea, vomiting, and behaviors indicative of malaise. Rats and mice, and probably all rodents, do not possess a vomiting response, and their ingestion of kaolin clay (a pica response) has been used as an index of malaise. Similar to the action of cisplatin on emesis in vomiting species, in the rat cisplatin activates vagal afferent fibers, and cisplatin-induced kaolin intake is largely dependent on an intact abdominal vagus. Cisplatin also stimulates Fos expression in the rat brain in areas known to play a role in emesis in other species, but it is not known whether vagal input is required for this CNS activation. In the present study, rats were given abdominal vagotomy or sham operation to test the role of an intact vagus on cisplatin-induced Fos expression 6 h after injection with saline or cisplatin (6 mg/kg, ip). Cisplatin treatment produced Fos expression in the area postrema and multiple levels of the nucleus of the solitary tract (NTS) of sham-operated rats. Vagotomy reduced cisplatin-induced Fos expression in the caudal and middle levels of the NTS and central amygdala. Furthermore, cisplatin did not significantly alter Fos expression in the spinal cord (T8-T10) before or after vagotomy. These results suggest that a defined portion of cisplatin-induced Fos expression is dependent on vagal input, with a majority of this response determined by either direct action of cisplatin or humoral factors on the CNS.
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