ArticleThe Journal of allergy and clinical immunology2009
Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS.
Article in The Journal of allergy and clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins.International journal of environmental research and public health · 2021Review
- Gestational diabetes is associated with changes in placental microbiota and microbiome.Pediatric research · 2016Article
- Prenatal and postnatal stress and asthma in children: Temporal- and sex-specific associations.The Journal of allergy and clinical immunology · 2016Article
- CD4⁺ and CD8⁺ T cells play a central role in a HDM driven model of allergic asthma.Respiratory research · 2016Article
- Evaluation of in utero sensitization by screening antigen-specific immunoglobulin E levels in umbilical cord blood.Postepy dermatologii i alergologii · 2015Article
- Article
- Environmental assessment and exposure control of dust mites: a practice parameter.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Article
- Maternal infection in pregnancy and risk of asthma in offspring.Maternal and child health journal · 2013Article
- Maternal occupational exposure to asthmogens during pregnancy and risk of asthma in 7-year-old children: a cohort study.BMJ open · 2013Article
- Prenatal and postnatal maternal stress and wheeze in urban children: effect of maternal sensitization.American journal of respiratory and critical care medicine · 2012Article
- Article
- Prenatal negative life events increases cord blood IgE: interactions with dust mite allergen and maternal atopy.Allergy · 2012Article
- Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study.BMC pulmonary medicine · 2012Article
- Different implications of paternal and maternal atopy for perinatal IgE production and asthma development.Clinical & developmental immunology · 2012Review
- Association of house dust mite-specific IgE with asthma control, medications and household pets.Asia Pacific allergy · 2011Article
- Associations among maternal childhood socioeconomic status, cord blood IgE levels, and repeated wheeze in urban children.The Journal of allergy and clinical immunology · 2011Article
- Exposure to moderate air pollution during late pregnancy and cord blood cytokine secretion in healthy neonates.PloS one · 2011Article
- Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort.American journal of respiratory and critical care medicine · 2010Article
- Does exposure to indoor allergens contribute to the development of asthma and allergy?Current allergy and asthma reports · 2010Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWhereas some evidence suggests that antigen sensitization may begin prenatally, the influence of maternal allergen exposure during pregnancy has not been fully elucidated.
objectivesWe examined the relationship between prenatal maternal aeroallergen exposure and cord blood total IgE and the potential mediating/indirect effect of maternal immune response.
methodsThis study was performed in 301 mother-infant pairs enrolled in the Asthma Coalition on Community, Environment, and Social Stress (ACCESS) project, a study examining the effects of prenatal and early life social and physical environmental exposures on urban asthma risk. Dust samples collected prenatally from mothers' bedrooms were analyzed for cockroach and dust mite allergens. Cord blood was analyzed for total IgE, and maternal serum collected during pregnancy for total and specific IgE. We assessed the relationship between prenatal exposure and cord blood total IgE and the potential mediation effect adjusting for maternal age, race, education, smoking status, and dust collection season; and child's sex and season of birth.
resultsIn multivariate models, elevated prenatal dust mite levels (>0.2 microg/g) increased cord blood IgE concentrations by 29% (P = .08), and continuous dust mite concentration was associated with a significant nonlinear increase in cord blood IgE (P = .02). Elevated prenatal exposure to cockroach allergen (>2 U/g) was not associated with cord blood IgE, but showed a significant indirect relationship through maternal total IgE (beta = 0.23; 95% CI, 0.08-0.41).
conclusionThese results demonstrate that maternal prenatal exposure to household allergens may affect cord blood IgE, albeit the underlying mechanism may be allergen-specific.
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