Evidence map›Paper›PMID 19361514›Full record

ReviewJournal of molecular and cellular cardiology2009

What keeps us ticking: a funny current, a calcium clock, or both?

Edward G Lakatta, Dario DiFrancesco

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed.

  1. Article
  2. Review
  3. On the mechanism of control of the pulse rate.Experimental physiology · 2026
    Article
  4. Article
  5. Emerging Regulatory Mechanisms in Sinoatrial Node Automaticity.Journal of cellular and molecular medicine · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Cardiac muscle physiology.BJA education · 2023
    Review
  14. Review
  15. Article
  16. Compartmentalized cAMP signalling and control of cardiac rhythm.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  17. Article
  18. Article
  19. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  20. Regenerative therapy · 2022
    Article

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Edward G LakattaLaboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, USA. LakattaE@grc.nia.nih.gov
Dario DiFrancesco

Funding

Decreased pacemaker activity in aged sinoatrial nodeZIAAG000262 · NIA · NATIONAL INSTITUTE ON AGING · PI LAKATTA, EDWARD · 2009 to 2025
$5.8M
Ca2+-stimulated Basal Adenylyl Cyclase Activity Localization in Membrane LipidZIAAG000258 · NIA · NATIONAL INSTITUTE ON AGING · PI LAKATTA, EDWARD · 2009 to 2019
$3.1M
Cultured adult rabbit pacemaker cells for gene transfer studiesZIAAG000232 · NIA · NATIONAL INSTITUTE ON AGING · PI LAKATTA, EDWARD · 2009 to 2025
$2.7M
Intramural NIH HHS ZIA AG000258
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biological ClocksIon Channel GatingAnimalsArrhythmias, CardiacCalciumCyclic Nucleotide-Gated Cation ChannelsHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium ChannelsTime FactorsCalciumCyclic Nucleotide-Gated Cation ChannelsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium Channels

Identifiers

PMID19361514
PMCPMC4554526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.