Evidence map›Paper›PMID 19361254›Full record

ReviewAntioxidants & redox signaling2009

Angiomyogenesis for myocardial repair.

Husnain Kh Haider, Syed Ali Akbar, Muhammad Ashraf

Abstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Angiogenesis in the infarcted myocardium.Antioxidants & redox signaling · 2013
    Review
  11. Regulation of angiogenesis by hypoxia: the role of microRNA.Cellular & molecular biology letters · 2013
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Husnain Kh HaiderDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0529, USA. haiderkh@ucmail.uc.edu
Syed Ali Akbar
Muhammad Ashraf

Funding

Stem Cells in Cardiac Repair and AngiogenesisR37HL074272 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ASHRAF, MUHAMMAD · 2003 to 2013
$5.7M
Cardiac Repair Using Smart Stem CellsR01HL087246 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ASHRAF, MUHAMMAD · 2007 to 2011
$2.8M
Mechanistic basis of myoblast therapy &angiomyogenesisR01HL080686 · NHLBI · UNIVERSITY OF CINCINNATI · PI ASHRAF, MUHAMMAD · 2005 to 2009
$2.7M
Preconditioning and re-programming of stem cells for cardiac repairR01HL087288 · NHLBI · UNIVERSITY OF CINCINNATI · PI HABEEBAHMED, RAFEEQ, HAIDER, KHAWAJA H · 2008 to 2012
$1.9M
Simltaneous recruitment of cardiac and bone marrow stem cells for cardiac repairR01HL089535 · NHLBI · UNIVERSITY OF CINCINNATI · PI HAIDER, KHAWAJA H · 2008 to 2012
$1.9M
NHLBI NIH HHS HL-080686NHLBI NIH HHS HL087246NHLBI NIH HHS HL087288NHLBI NIH HHS HL089535NHLBI NIH HHS R01 HL080686NHLBI NIH HHS R01 HL087246NHLBI NIH HHS R01 HL087288NHLBI NIH HHS R01 HL089535NHLBI NIH HHS R37 HL074272NHLBI NIH HHS R37-HL074272
6 · The paper itself

Abstract

The conventional therapeutic modalities for myocardial infarction have limited success in preventing the progression of left ventricular remodeling and congestive heart failure. The heart cell therapy and therapeutic angiogenesis are two promising strategies for the treatment of ischemic heart disease. After extensive assessment of safety and effectiveness in vitro and in experimental animal studies, both of these approaches have accomplished the stage of clinical utility, albeit with limited success due to the inherent limitations and problems of each approach. Neomyogenesis without restoration of regional blood flow may be less meaningful. A combined stem-cell and gene-therapy approach of angiomyogenesis is expected to yield better results as compared with either of the approaches as a monotherapy. The combined therapy approach will help to restore the mechanical contractile function of the weakened myocardium and alleviate ischemic condition by restoration of regional blood flow. In providing an overview of both stem cell therapy and gene therapy, this article is an in-depth and critical appreciation of combined cell and gene therapy approach for myocardial repair.

Indexed as

Genetic TherapyNeovascularization, PathologicStem Cell TransplantationAnimalsMyocardial IschemiaRats

Identifiers

PMID19361254
PMCPMC2848517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.