ArticleAutism research : official journal of the International Society for Autism Research2008
A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders.
Article in Autism research : official journal of the International Society for Autism Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Rare Opportunities for Insights Into Serotonergic Contributions to Brain and Bowel Disorders: Studies of the SERT Ala56 Mouse.Frontiers in cellular neuroscience · 2021Article
- Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- The serotonin system in autism spectrum disorder: From biomarker to animal models.Neuroscience · 2016Review
- The Impact of Neuroimmune Alterations in Autism Spectrum Disorder.Frontiers in psychiatry · 2015Review
- Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice.Molecular autism · 2013Article
- Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome.Molecular autism · 2013Article
- Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Ontogeny and regulation of the serotonin transporter: providing insights into human disorders.Pharmacology & therapeutics · 2011Review
- Confronting two-pair primer design for enzyme-free SNP genotyping based on a genetic algorithm.BMC bioinformatics · 2010Article
- Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder.Journal of autism and developmental disorders · 2010Article
- Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse.Journal of neurodevelopmental disorders · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In the current study we explored the hypothesis that rare variants in SLC6A4 contribute to autism susceptibility and to rigid-compulsive behaviors in autism. We made use of a large number of unrelated cases with autism spectrum disorders (approximately 350) and controls (approximately 420) and screened for rare exonic variants in SLC6A4 by a high-throughput method followed by sequencing. We observed no difference in the frequency of such variants in the two groups, irrespective of how we defined the rare variants. Furthermore, we did not observe an association of rare coding variants in SLC6A4 with rigid-compulsive traits scores in the cases. These results do not support a significant role for rare coding variants in SLC6A4 in autism spectrum disorders, nor do they support a significant role for SLC6A4 in rigid-compulsive traits in these disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.