ArticleAutism research : official journal of the International Society for Autism Research2008
Perceptual metrics of individuals with autism provide evidence for disinhibition.
Article in Autism research : official journal of the International Society for Autism Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Family life and autistic children with sensory processing differences: A qualitative evidence synthesis of occupational participation.Frontiers in psychology · 2022Pooled it
- Effects of the N-methyl-D-Aspartate receptor antagonist dextromethorphan on vibrotactile adaptation.BMC neuroscience · 2008Trial
- Atypical Tactile Perception in Early Childhood Autism.Journal of autism and developmental disorders · 2023Article
- Circuit-level theories for sensory dysfunction in autism: convergence across mouse models.Frontiers in neurology · 2023Review
- Methodology of the INVestigating traIning assoCiated blasT pAthology (INVICTA) study.BMC medical research methodology · 2022Article
- Visual illusion susceptibility in autism: A neural model.The European journal of neuroscience · 2022Article
- Nonlinear age effects in tactile processing from early childhood to adulthood.Brain and behavior · 2022Article
- Tactile cortical responses and association with tactile reactivity in young children on the autism spectrum.Molecular autism · 2021Article
- Sensory Overresponsivity as a Predictor of Amplitude Discrimination Performance in Youth with ASD.Journal of autism and developmental disorders · 2020Article
- Reproducibility of flutter-range vibrotactile detection and discrimination thresholds.Scientific reports · 2020Article
- A Critical Review of Behavioral and Emotional Disinhibition.The Journal of nervous and mental disease · 2020Review
- On the central role of mitochondria dysfunction and oxidative stress in Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Review
- Article
- Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex.Neural plasticity · 2019Article
- Article
- Autism spectrum disorder in the scope of tactile processing.Developmental cognitive neuroscience · 2018Review
- The impact of atypical sensory processing on social impairments in autism spectrum disorder.Developmental cognitive neuroscience · 2018Review
- Altered tactile sensitivity in children with attention-deficit hyperactivity disorder.Journal of neurophysiology · 2017Article
- Autonomic versus perceptual accounts for tactile hypersensitivity in autism spectrum disorder.Scientific reports · 2017Article
- Reduced GABA and altered somatosensory function in children with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Adults with autism exhibit inhibitory deficits that are often manifested in behavioral modifications, such as repetitive behaviors, and/or sensory hyper-responsiveness. If such behaviors are the result of a generalized deficiency in inhibitory neurotransmission, then it stands to reason that deficits involving localized cortical-cortical interactions--such as in sensory discrimination tasks--could be detected and quantified. This study exemplifies a newly developed method for quantifying sensory testing metrics. Our novel sensory discrimination tests may provide (a) an effective means for biobehavioral assessment of deficits specific to autism and (b) an efficient and sensitive measure of change following treatment. The sensory discriminative capacity of ten subjects with autism and ten controls was compared both before and after short duration adapting stimuli. Specifically, vibrotactile amplitude discriminative capacity was obtained both in the presence and absence of 1 sec adapting stimuli that were delivered 1 sec prior to the comparison stimuli. Although adaptation had a pronounced effect on the amplitude discriminative capacity of the control subjects, little or no impact was observed on the sensory discriminative capacity of the subjects with autism. This lack of impact of the adapting stimuli on the responses of the subjects with autism was interpreted to be consistent with the reduced GABAergic-mediated inhibition described in previous reports. One significant aspect of this study is that the methods could prove to be a useful and efficient way to detect specific neural deficits and monitor the efficacy of pharmacological or behavioral treatments in autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.