ArticleAutism research : official journal of the International Society for Autism Research2008
Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.
Article in Autism research : official journal of the International Society for Autism Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Evidence of susceptibility to autism risks associated with early life ambient air pollution: A systematic review.Environmental research · 2022Pooled it
- Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway.Cells · 2022Article
- Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer.Molecular cancer · 2022Review
- Identification of a Novel Small RNA Encoded in the Mouse Urokinase Receptor uPAR Gene (Frontiers in molecular neuroscience · 2022Article
- Connecting the Neurobiology of Developmental Brain Injury: Neuronal Arborisation as a Regulator of Dysfunction and Potential Therapeutic Target.International journal of molecular sciences · 2021Review
- Article
- Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders.Journal of neurodevelopmental disorders · 2020Article
- Control of cortical synapse development and plasticity by MET receptor tyrosine kinase, a genetic risk factor for autism.Journal of neuroscience research · 2020Review
- Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer.EJNMMI research · 2020Review
- Beyond the brain: A multi-system inflammatory subtype of autism spectrum disorder.Psychopharmacology · 2019Review
- Extracellular signal-regulated kinase 2 has duality in function between neuronal and astrocyte expression following neonatal hypoxic-ischaemic cerebral injury.The Journal of physiology · 2018Article
- Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation.Neuromolecular medicine · 2018Review
- Heritable genotype contrast mining reveals novel gene associations specific to autism subgroups.Journal of biomedical informatics · 2018Article
- Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review.Frontiers in psychiatry · 2018Review
- Mechanisms regulating dendritic arbor patterning.Cellular and molecular life sciences : CMLS · 2017Review
- MicroRNA-7-5p mediates the signaling of hepatocyte growth factor to suppress oncogenes in the MCF-10A mammary epithelial cell.Scientific reports · 2017Article
- Pregnancy at Advanced Maternal Age Affects Behavior and Hippocampal Gene Expression in Mouse Offspring.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Altered gene expression in early postnatal monoamine oxidase A knockout mice.Brain research · 2017Article
- Autoimmunity, Autoantibodies, and Autism Spectrum Disorder.Biological psychiatry · 2017Review
- Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions.Autism research : official journal of the International Society for Autism Research · 2017Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
A functional promoter variant of the gene encoding the MET receptor tyrosine kinase alters SP1 and SUB1 transcription factor binding, and is associated with autism spectrum disorder (ASD). Recent analyses of postmortem cerebral cortex from ASD patients revealed altered expression of MET protein and three transcripts encoding proteins that regulate MET signaling, hepatocyte growth factor (HGF), urokinase plasminogen activator receptor (PLAUR) and plasminogen activator inhibitor-1 (SERPINE1). To address potential risk conferred by multiple genes in the MET signaling pathway, we screened all exons and 5' promoter regions for variants in the five genes encoding proteins that regulate MET expression and activity. Identified variants were genotyped in 664 families (2,712 individuals including 1,228 with ASD) and 312 unrelated controls. Replicating our initial findings, family-based association test (FBAT) analyses demonstrated that the MET promoter variant rs1858830 C allele was associated with ASD in 101 new families (P=0.033). Two other genes in the MET signaling pathway also may confer risk. A haplotype of the SERPINE1 gene exhibited significant association. In addition, the PLAUR promoter variant rs344781 T allele was associated with ASD by both FBAT (P=0.006) and case-control analyses (P=0.007). The PLAUR promoter rs344781 relative risk was 1.93 (95% confidence interval [CI]: 1.12-3.31) for genotype TT and 2.42 (95% CI: 1.38-4.25) for genotype CT compared to genotype CC. Gene-gene interaction analyses suggested a significant interaction between MET and PLAUR. These data further support our hypothesis that genetic susceptibility impacting multiple components of the MET signaling pathway contributes to ASD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.