ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2009
Salvage chemotherapy for metastatic and recurrent ependymoma of childhood.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series.The oncologist · 2019Trial
- An open-label, two-stage, phase II study of bevacizumab and lapatinib in children with recurrent or refractory ependymoma: a collaborative ependymoma research network study (CERN).Journal of neuro-oncology · 2015Trial
- Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study.Neuro-oncology · 2012Trial
- Posterior fossa ependymoma: a comprehensive review of molecular classification, management guidelines, and clinical outcomes (Part I of ependymomas across compartments).Journal of neuro-oncology · 2026Review
- Two Decades of Childhood Ependymoma Experience at a Tertiary Cancer Center in Turkey.Children (Basel, Switzerland) · 2026Article
- A brief history of ependymoma.Neuro-oncology · 2026Review
- Treatment and outcome of pediatric intracranial ependymoma after first relapse.Journal of neuro-oncology · 2022Article
- Review
- Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies.Journal of neuro-oncology · 2021Article
- Local and systemic therapy of recurrent ependymoma in children and adolescents: short- and long-term results of the E-HIT-REZ 2005 study.Neuro-oncology · 2021Article
- Long-term outcomes from the second l'Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP) protocol.Neuro-oncology · 2021Article
- Current and Emerging Methods of Management of Ependymoma.Current oncology reports · 2019Review
- Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma.Acta neuropathologica communications · 2016Article
- Re-irradiation of recurrent pediatric ependymoma: modalities and outcomes: a twenty-year survey.SpringerPlus · 2016Article
- Reirradiation of Recurrent Pediatric Brain Tumors after Initial Proton Therapy.International journal of particle therapy · 2016Article
- Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma.Neuro-oncology · 2015Article
- Posterior fossa ependymoma: current insights.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
- Fractionated stereotactic radiosurgery for recurrent ependymoma in children.Journal of neuro-oncology · 2014Article
- Super-selective basilar artery infusion of bevacizumab and cetuximab for multiply recurrent pediatric ependymoma.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2011Article
- mTORC1 activation in childhood ependymoma and response to sirolimus.Journal of neuro-oncology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChemotherapy has limited role in the up-front management of ependymoma. At the time of recurrence, the role of chemotherapy is also ill defined and the choice of chemotherapeutic agents is often arbitrary, based on anecdotal data and personal experience.
methodsThe purpose of this review is to describe and critically analyze the published literature on chemotherapy in patients with recurrent and metastatic ependymoma. DISCUSSION: The disappointing response rate with single agents (12.9%) and combinations (17.4%) emphasizes the need to re-evaluate the current chemotherapeutic approach of intracranial ependymoma, and biological studies are needed to identify targets that may be considered for clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.