ArticleThe Journal of trauma2009
Regulation of signaling pathways downstream of IGF-I/insulin by androgen in skeletal muscle of glucocorticoid-treated rats.
Article in The Journal of trauma, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer.Pharmaceuticals (Basel, Switzerland) · 2023Review
- A narrative review of skeletal muscle atrophy in critically ill children: pathogenesis and chronic sequelae.Translational pediatrics · 2021Review
- Is Mitochondrial Oxidative Stress the Key Contributor to Diaphragm Atrophy and Dysfunction in Critically Ill Patients?Critical care research and practice · 2020Review
- Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease.Frontiers in neuroscience · 2018Review
- Sex ModulatesFrontiers in microbiology · 2018Article
- The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia.Osteoporosis and sarcopenia · 2016Review
- Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance.Journal of the International Society of Sports Nutrition · 2016Review
- Insulin down-regulates the expression of ubiquitin E3 ligases partially by inhibiting the activity and expression of AMP-activated protein kinase in L6 myotubes.Bioscience reports · 2015Article
- Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications.Tissue engineering. Part B, Reviews · 2014Review
- Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.American journal of physiology. Endocrinology and metabolism · 2014Review
- Metabolic functions of glucocorticoid receptor in skeletal muscle.Molecular and cellular endocrinology · 2013Review
- Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.Molecular and cellular endocrinology · 2013Article
- Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment.American journal of physiology. Endocrinology and metabolism · 2011Article
- Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered.Respiratory research · 2010Article
- Hormone treatment and muscle anabolism during aging: androgens.Clinical nutrition (Edinburgh, Scotland) · 2010Review
- Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization.American journal of physiology. Endocrinology and metabolism · 2010Article
- Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation.Current opinion in clinical nutrition and metabolic care · 2010Review
- Time course expression of Foxo transcription factors in skeletal muscle following corticosteroid administration.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Changes in the natural abundance of 13CO2/12CO2 in breath due to lipopolysacchride-induced acute phase response.Rapid communications in mass spectrometry : RCM · 2009Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe mechanisms by which androgens ameliorate glucocorticoid-induced muscle wasting are still under investigation. In the present study, we tested the hypothesis that androgen's effects in reversing muscle wasting are related to activating the signaling pathways downstream of insulin-like growth factor-1 (IGF-I)/insulin.
methodsForty female Sprague-Dawley rats were randomly divided into four groups: control group, dexamethasone (DEX) group, testosterone (TES) group, and TES + DEX group. Each group was injected with saline or DEX (0.1 mg/100 g/d) for 10 days and sesame oil or TES (0.5 mg/100 g/d) for 13 days. Several downstream targets of IGF-I/insulin in skeletal muscle including protein kinase B (Akt), p70 ribosomal protein S6 kinase (p70S6K), and glycogen synthase kinase-3beta (GSK-3beta) that are associated with protein synthesis were examined. Two proteolysis-related ubiquitin E3-ligases, muscle atrophy F-box, and muscle RING finger-1 that are also regulated by IGF-I/insulin were also assessed.
resultsTES attenuated gastrocnemius muscle atrophy induced by DEX. TES prevented the DEX-induced decrease of IGF-I expression in gastrocnemius muscle, but not in serum. TES ameliorated DEX-induced dephosphorylation of Akt and p70S6K and promoted the phosphorylation of GSK-3beta in gastrocnemius muscle. The total amount of Akt, p70S6K, or GSK-3beta proteins was not changed among these groups. TES did not show any effects on the DEX-induced upregulation of muscle atrophy F-box, and muscle RING finger-1 mRNA in gastrocnemius muscle.
conclusionThis findings suggest that the effects of TES in reversing DEX-induced muscle atrophy are related to signaling pathways downstream of IGF-I/insulin that are associated with protein synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.