ReviewScience (New York, N.Y.)2009
Multiscale modeling of form and function.
Review in Science (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed.
- Forcing the code: tension modulates signaling to drive morphogenesis and malignancy.Genes & development · 2025Review
- Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories.Cell stress · 2025Review
- Classification of collagen remodeling in asthma using second-harmonic generation imaging, supervised machine learning and texture-based analysis.Frontiers in bioinformatics · 2025Article
- Article
- Conformational Changes in Surface-Immobilized Proteins Measured Using Combined Atomic Force and Fluorescence Microscopy.Molecules (Basel, Switzerland) · 2023Article
- Reciprocity of Cell Mechanics with Extracellular Stimuli: Emerging Opportunities for Translational Medicine.Small (Weinheim an der Bergstrasse, Germany) · 2022Review
- TGFβ-induced changes in membrane curvature influence Ras oncoprotein membrane localization.Scientific reports · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- Article
- Review
- Review
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- The Breast Tumor Microenvironment: Could Silicone Breast Implant Elicit Breast Carcinoma?Breast cancer (Dove Medical Press) · 2021Article
- Computational Biology andCurrent opinion in toxicology · 2020Article
- Mutually exclusive locales for N-linked glycans and disorder in human glycoproteins.Scientific reports · 2020Article
- Understanding biochemical processes in the presence of sub-diffusive behavior of biomolecules in solution and living cells.Biophysical reviews · 2019Review
- The Order of Cancer: A Theory of Malignant Progression by Inverse Morphogenesis.Frontiers in oncology · 2019Article
- 3D Inkjet Printing of Complex, Cell-Laden Hydrogel Structures.Scientific reports · 2018Article
- The Effect of Mammary Extracellular Matrix in Controlling Oral and Mammary Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Mechanical feedback coordinates cell wall expansion and assembly in yeast mating morphogenesis.PLoS computational biology · 2018Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Topobiology posits that morphogenesis is driven by differential adhesive interactions among heterogeneous cell populations. This paradigm has been revised to include force-dependent molecular switches, cell and tissue tension, and reciprocal interactions with the microenvironment. It is now appreciated that tissue development is executed through conserved decision-making modules that operate on multiple length scales from the molecular and subcellular level through to the cell and tissue level and that these regulatory mechanisms specify cell and tissue fate by modifying the context of cellular signaling and gene expression. Here, we discuss the origin of these decision-making modules and illustrate how emergent properties of adhesion-directed multicellular structures sculpt the tissue, promote its functionality, and maintain its homeostasis through spatial segregation and organization of anchored proteins and secreted factors and through emergent properties of tissues, including tension fields and energy optimization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.