ArticleProceedings of the National Academy of Sciences of the United States of America2009
WIP is critical for T cell responsiveness to IL-2.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- DIAPH1-Deficiency is Associated with Major T, NK and ILC Defects in Humans.Journal of clinical immunology · 2024Article
- Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ.Oncogene · 2017Article
- αII-spectrin in T cells is involved in the regulation of cell-cell contact leading to immunological synapse formation?PloS one · 2017Article
- A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.The Journal of clinical investigation · 2016Article
- Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.Molecular and cellular biology · 2014Article
- Actin engine in immunological synapse.Immune network · 2012Article
- A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP.The Journal of experimental medicine · 2012Article
- WIP remodeling actin behind the scenes: how WIP reshapes immune and other functions.International journal of molecular sciences · 2012Review
- Proline rich motifs as drug targets in immune mediated disorders.International journal of peptides · 2012Article
- The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling.Haematologica · 2011Article
- Review
- Cortactin: a multifunctional regulator of cellular invasiveness.Cell adhesion & migrationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The Wiskott-Aldrich syndrome (WAS) interacting protein (WIP) stabilizes the WAS protein (WASP), the product of the gene mutated in WAS. WIP-deficient T cells have low WASP levels, limiting the usefulness of WIP KO mice in defining the role of WIP in T cell function. To define this role, we compared WIP/WASP double KO (DKO) mice to WASP KO mice on DO11.10 background. T cell development was normal in both strains, but peripheral T cell numbers were significantly decreased in DKO mice. WASP KO T cells proliferated and secreted IL-2 normally in response to OVA peptide (OVAp). In contrast, T cells from DKO mice proliferated poorly in response to OVAp in vitro, and cutaneous hapten hypersensitivity was deficient in these mice. DKO T cells up-regulated CD25 expression and secreted normal amounts of IL-2 after antigen stimulation, but had defective response to IL-2, evidenced by failure to further up-regulate CD25 expression, phosphorylate STAT5, and induce expression of STAT5-dependent genes. DKO, but not WASP KO, T cells had a disrupted subcortical actin cytoskeleton and impaired actin polymerization after T cell antigen receptor (TCR) ligation. These results indicate that WIP is essential for IL-2 signaling and responsiveness in T cells, possibly because of its critical role in TCR-triggered actin cytoskeletal reorganization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.