ArticleProceedings of the National Academy of Sciences of the United States of America2009
Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03236558 (Thymic Generation of Regulatory T Lymphocytes in Type I Diabetes Patients.), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thymic Generation of Regulatory T Lymphocytes in Type I Diabetes Patients.
Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- The 'TNature reviews. Rheumatology · 2025Review
- Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection.Frontiers in endocrinology · 2024Review
- The type 1 diabetes susceptibility locusFrontiers in immunology · 2024Article
- The evolution of powerful yet perilous immune systems.Trends in immunology · 2022Review
- Article
- Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Haploidentical mixed chimerism cures autoimmunity in established type 1 diabetic mice.The Journal of clinical investigation · 2020Article
- Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.Annals of the New York Academy of Sciences · 2020Review
- Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging.Immunity & ageing : I & A · 2020Review
- The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes.Frontiers in immunology · 2020Review
- Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.Clinical and experimental immunology · 2019Article
- High Thymic Output of Effector CD4Journal of immunology research · 2019Article
- Patients withBlood · 2018Article
- Thymic B Cell-Mediated Attack of Thymic Stroma Precedes Type 1 Diabetes Development.Frontiers in immunology · 2018Article
- T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes.Nature communications · 2017Article
- Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response.Frontiers in immunology · 2017Review
- Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Article
- Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Thymus-derived Foxp3(+) natural regulatory CD4 T cells (nTregs) prevent autoimmunity through control of pathogenic, autoreactive T cells and other immune effector cells. Using T cell receptor (TCR) transgenic models, diversity within this lineage has been found to be similar to that of conventional CD4 T cells. To determine whether balanced TCR diversity may be perturbed in autoimmunity, we have analyzed receptor composition in C57BL/6 and autoimmune non-obese diabetic (NOD) mice. The natural regulatory and conventional CD4 repertoires of C57BL/6 had similar diversities. Despite the apparently normal thymic development of the NOD nTreg lineage, TCR diversity within the selected repertoire was markedly restricted. Detailed analysis of TCRalpha and -beta chain composition is consistent with positive selection into the natural regulatory lineage being under stringent audition for interaction with MHC class II/self-peptide. The NOD MHC region, including the unique H2-A(g7) class II molecule, partly accounts for the reduction in diversity, but additional NOD genetic contribution(s) are required for complete repertoire compaction. Mechanistic links between MHC, autoimmunity, and nTreg diversity identified in this study are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.