ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Prostaglandin regulation of gastric slow waves and peristalsis.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Abnormal bowel movement frequency increases the risk of rectal cancer: evidence from cohort studies with one million people.Bioscience reports · 2020Pooled it
- The Functional Study of Prostaglandin EChonnam medical journal · 2026Article
- Differential responses to prostaglandins in the circular and longitudinal muscle layers of the murine ileum.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Article
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Development and validation of a dual-energy CT-based model to estimate the malignant probability of distal gastric wall thickening.Journal of gastrointestinal oncology · 2022Article
- CaCell calcium · 2021Article
- Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches.Frontiers in physiology · 2020Article
- The Role of Prostaglandins in Disrupted Gastric Motor Activity Associated With Type 2 Diabetes.Diabetes · 2019Article
- Smooth muscle atrophy and colon pathology in SMN deficient mice.American journal of translational research · 2019Article
- Prostanoid EP3 receptor agonist sulprostone enhances pacemaker activity of colonic interstitial cells of Cajal.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Regulation of gastric electrical and mechanical activity by cholinesterases in mice.Journal of neurogastroenterology and motility · 2015Article
- Recent progress in gastric arrhythmia: pathophysiology, clinical significance and future horizons.Clinical and experimental pharmacology & physiology · 2014Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Role of lubiprostone on gastrointestinal motility.Journal of neurogastroenterology and motility · 2013Article
- Analysis of pacemaker activity in the human stomach.The Journal of physiology · 2011Article
- Movement based artifacts may contaminate extracellular electrical recordings from GI muscles.Neurogastroenterology and motility · 2011Article
- High-resolution spatial analysis of slow wave initiation and conduction in porcine gastric dysrhythmia.Neurogastroenterology and motility · 2011Article
- Origin, propagation and regional characteristics of porcine gastric slow wave activity determined by high-resolution mapping.Neurogastroenterology and motility · 2010Article
- ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine.Neurogastroenterology and motility · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Gastric emptying depends on functional coupling of slow waves between the corpus and antrum, to allow slow waves initiated in the gastric corpus to propagate to the pyloric sphincter and generate gastric peristalsis. Functional coupling depends on a frequency gradient where slow waves are generated at higher frequency in the corpus and drive the activity of distal pacemakers. Simultaneous intracellular recording from corpus and antrum was used to characterize the effects of PGE(2) on slow waves in the murine stomach. PGE(2) increased slow-wave frequency, and this effect was mimicked by EP(3), but not by EP(2), receptor agonists. Chronotropic effects were due to EP(3) receptors expressed by intramuscular interstitial cells of Cajal because these effects were not observed in W/W(V) mice. Although the integrated chronotropic effects of EP(3) receptor agonists were deduced from electrophysiological experiments, no clear evidence of functional uncoupling was observed with two-point electrical recording. Gastric peristalsis was also monitored by video imaging and spatiotemporal maps to study the impact of chronotropic agonists on propagating contractions. EP(3) receptor agonists increased the frequency of peristaltic contractions and caused ectopic sites of origin and collisions of peristaltic waves. The impact of selective regional application of chronotropic agonists was investigated by use of a partitioned bath. Antral slow waves followed enhanced frequencies induced by stimulation of the corpus, and corpus slow waves followed when slow-wave frequency was elevated in the antrum. This demonstrated reversal of slow-wave propagation with selective antral chronotropic stimulation. These studies demonstrate the impact of chronotropic agonists on regional intrinsic pacemaker frequency and integrated gastric peristalsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.