ArticleBlood2009
Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA).
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Quantifying telomere length: from bulk assays to single-molecule resolution.Biophysics reports · 2026Article
- Tracking single-cell evolution using clock-like chromatin accessibility loci.Nature biotechnology · 2025Article
- Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications.Frontiers in bioengineering and biotechnology · 2024Review
- Telomere integrated scoring system of myelodysplastic syndrome.Journal of clinical laboratory analysis · 2023Article
- Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita.Blood · 2022Article
- Sample path properties of the average generation of a Bellman-Harris process.Journal of mathematical biology · 2019Article
- Evaluating Interaction of Cord Blood Hematopoietic Stem/Progenitor Cells with Functionally Integrated Three-Dimensional Microenvironments.Stem cells translational medicine · 2018Article
- Telomere Length Dynamics and the Evolution of Cancer Genome Architecture.International journal of molecular sciences · 2018Review
- Shorter leukocyte telomere length is associated with higher risk of infections: a prospective study of 75,309 individuals from the general population.Haematologica · 2017Article
- Inferring average generation via division-linked labeling.Journal of mathematical biology · 2016Article
- Reactive oxygen species in cancer stem cells.Antioxidants & redox signaling · 2012Review
- Telomere length measurement-caveats and a critical assessment of the available technologies and tools.Mutation research · 2012Review
- Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes.PLoS genetics · 2012Article
- Telomere biology in hematopoiesis and stem cell transplantation.Blood reviews · 2011Review
- Article
- Predicting clonal self-renewal and extinction of hematopoietic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Human endothelial stem/progenitor cells, angiogenic factors and vascular repair.Journal of the Royal Society, Interface · 2010Review
- Synchrony of telomere length among hematopoietic cells.Experimental hematology · 2010Article
- Umbilical cord transplantation: epilogue.Seminars in hematology · 2010Review
- Humanized culture medium for clinical expansion of human erythroblasts.Cell transplantation · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
In most human somatic cells, telomeres shorten as a function of DNA replication. Telomere length is therefore an indirect measure of the replicative history of cells. We measured the telomere lengths at XpYp chromosomes in purified human hematopoietic populations enriched for stem cells (Lin(-)CD34(+)CD38(-)Rho(-)) and successively more mature cells. The average telomere length showed expected length changes, pointing to the utility of this method for classifying novel differentiation markers. Interestingly, the frequency of abruptly shortened telomeres increased in terminally differentiated adult populations, suggesting that damage to telomeric DNA occurs or is not repaired upon hematopoietic differentiation. When Lin(-)CD34(+)CD38(-)Rho(-) cord blood cells were transplanted into immunodeficient mice, the telomeres of the most primitive regenerated human hematopoietic cells lost approximately 3 kb, indicative of more than 30 cell divisions. Further losses in differentiating cells were similar to those observed in pretransplantation cell populations. These results indicate extensive self-renewal divisions of human hematopoietic stem cells are the primary cause of telomere erosion upon transplantation rather than added cell divisions in downstream progenitors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.