ArticleNucleic acids research2009
Dramatic effect of single-base mutation on the conformational dynamics of human telomeric G-quadruplex.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Stability modification of therapeutic aptamers: from biostability bottlenecks to nuclease-resistant construct design.RSC chemical biology · 2026Review
- Atlas of telomeric repeat diversity in Arabidopsis thaliana.Genome biology · 2024Article
- Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation.Communications biology · 2023Article
- Noncanonical DNA structures are drivers of genome evolution.Trends in genetics : TIG · 2023Review
- Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues.Nucleic acids research · 2021Review
- Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.Nucleic acids research · 2021Article
- Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations.Nature communications · 2020Article
- Structural and Dynamical Characterization of DNA and RNA Quadruplexes Obtained from the GGGGCC and GGGCCT Hexanucleotide Repeats Associated with C9FTD/ALS and SCA36 Diseases.ACS chemical neuroscience · 2018Article
- Stability of the NaACS omega · 2018Article
- Molecular mechanisms by which oxidative DNA damage promotes telomerase activity.Nucleic acids research · 2017Article
- RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms.Journal of molecular biology · 2017Review
- Single-Molecule Studies of Telomeres and Telomerase.Annual review of biophysics · 2017Review
- Folding dynamics and conformational heterogeneity of human telomeric G-quadruplex structures in Na+ solutions by single molecule FRET microscopy.Nucleic acids research · 2016Article
- G-quadruplex formation in double strand DNA probed by NMM and CV fluorescence.Nucleic acids research · 2015Article
- Rationally manipulating aptamer binding affinities in a stem-loop molecular beacon.Bioconjugate chemistry · 2014Article
- G-quadruplex conformation and dynamics are determined by loop length and sequence.Nucleic acids research · 2014Article
- Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes.Nucleic acids research · 2011Article
- Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability.The FEBS journal · 2010Review
- The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts.Nucleic acids research · 2009Article
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2 authors.
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Abstract
Guanine-rich DNA sequences can form G-quadruplexes. These four-stranded structures are known to form in several genomic regions and to influence certain biological activities. Sometimes, the instability of G-quadruplexes causes the abnormal biological processes. Mutation is a culprit for the destabilization of G-quadruplexes, but the details of mutated G-quadruplexes are poorly understood. In this article, we investigated the conformational dynamics of single-base mutated human telomeric G-quadruplexes in the presence of K(+) with single-molecule FRET spectroscopy. We observed that the replacement of single guanine by thymine in a G-track induces various folded structures, i.e. structural polymorphism. Moreover, direct observation of their dynamics revealed that a single-base mutation causes fast unfolding of folded states under physiological conditions. Furthermore, we found that the degree of destabilization varies according to mutation positions. When the central guanine of a G-track is replaced, the G-quadruplexes unfold quickly at any K(+) concentrations and temperature. Meanwhile, outer-quartet mutated G-quadruplexes have heterogeneous dynamics at intermediate K(+) concentrations and longstanding folded states at high K(+) concentrations. Several factors such as base-stacking interaction and K(+) coordination are responsible for the different dynamics according to the mutation position.
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