ArticleJournal of medical genetics2009
A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length.
Article in Journal of medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.Nature communications · 2024Pooled it
- Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer's disease.Nature communications · 2022Pooled it
- Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort.Circulation. Cardiovascular genetics · 2014Pooled it
- Gender and telomere length: systematic review and meta-analysis.Experimental gerontology · 2014Pooled it
- Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.Human molecular genetics · 2012Pooled it
- Pooled it
- Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease.PloS one · 2013Trial
- Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases.Autophagy · 2022Article
- Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.Scientific reports · 2022Article
- Relationship between genetically determined telomere length and glioma risk.Neuro-oncology · 2022Article
- Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.Cell genomics · 2022Article
- Telomeres and Telomere Length: A General Overview.Cancers · 2020Review
- Article
- Identification of Leukocyte telomere length-related genetic variants contributing to predisposition of Esophageal Squamous Cell Carcinoma.Journal of Cancer · 2020Article
- Genetic variations associated with telomere length confer risk of gastric cardia adenocarcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019Article
- Genetic Determinants of Telomere Length in African American Youth.Scientific reports · 2018Article
- Significant SNPs Related to Telomere Length and Hepatocellular Carcinoma Risk in Chronic Hepatitis B CarriersAsian Pacific journal of cancer prevention : APJCP · 2018Review
- Telomeres, Aging and Exercise: Guilty by Association?International journal of molecular sciences · 2017Review
- Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series.Journal of the American College of Cardiology · 2017Review
- Telomere Length Assessment for Prediction of Organ Transplantation Outcome. Future or Failure: A Review of the Literature.Medical science monitor : international medical journal of experimental and clinical research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundTelomere length is a predictor for a number of common age related diseases and is a heritable trait. METHODS AND
resultsTo identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314,075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined = 2790). We identified two novel associated variants (rs2162440, p = 2.6 x 10(-6); and rs7235755, p = 5.5 x 10(-6)) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast.
conclusionThese results provide new insights into the pathways regulating telomere homeostasis in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.