ArticleThe EMBO journal1991
Translation of a polycistronic mRNA in the presence of the cauliflower mosaic virus transactivator protein.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 93 citations in OpenAlex.
- RNA-mediated translation regulation in viral genomes: computational advances in the recognition of sequences and structures.Briefings in bioinformatics · 2020Review
- Please do not recycle! Translation reinitiation in microbes and higher eukaryotes.FEMS microbiology reviews · 2018Review
- Ribosome Shunting, Polycistronic Translation, and Evasion of Antiviral Defenses in Plant Pararetroviruses and Beyond.Frontiers in microbiology · 2018Review
- Reinitiation after translation of two upstream open reading frames (ORF) governs expression of the ORF35-37 Kaposi's sarcoma-associated herpesvirus polycistronic mRNA.Journal of virology · 2014Article
- A molecular switch in the efficiency of translation reinitiation controls expression of var2csa, a gene implicated in pregnancy-associated malaria.Molecular microbiology · 2013Article
- Strategies for metabolic pathway engineering with multiple transgenes.Plant molecular biology · 2013Review
- Non-canonical translation in RNA viruses.The Journal of general virology · 2012Review
- A new plant protein interacts with eIF3 and 60S to enhance virus-activated translation re-initiation.The EMBO journal · 2009Article
- Virus versus host cell translation love and hate stories.Advances in virus research · 2009Review
- Article
- The cauliflower mosaic virus 35S promoter extends into the transcribed region.Journal of virology · 2004Article
- Eucaryotic initiation factor 4B controls eIF3-mediated ribosomal entry of viral reinitiation factor.The EMBO journal · 2004Article
- ARC-1, a sequence element complementary to an internal 18S rRNA segment, enhances translation efficiency in plants when present in the leader or intercistronic region of mRNAs.Nucleic acids research · 2004Article
- Article
- Protein-protein interactions required during translation.Plant molecular biology · 2002Review
- Contribution of downstream promoter elements to transcriptional regulation of the rice tungro bacilliform virus promoter.Nucleic acids research · 2002Article
- Viral strategies of translation initiation: ribosomal shunt and reinitiation.Progress in nucleic acid research and molecular biology · 2002Review
- Function of the intercistronic region of BRLF1-BZLF1 bicistronic mRNA in translating the zta protein of Epstein-Barr virus.Journal of virology · 2001Article
- Ribosome shunt is essential for infectivity of cauliflower mosaic virus.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycistronic mRNAs containing an upstream beta-glucuronidase (GUS) and a downstream chloramphenicol acetyltransferase (CAT) reporter open reading frame (ORF) were expressed in transfected plant protoplasts. CAT expression could be strongly induced by coexpression of the cauliflower mosaic virus encoded translation transactivator. Transactivation was abolished when an upstream ORF overlapped the CAT ORF for a long distance. No specific sequence elements were required for transactivation but the presence of a short ORF upstream of the GUS ORF strongly enhanced the process. The inhibitory effect of additional presumed stem structures inserted into various regions of the reporter mRNAs indicates that both ORFs are translated by ribosomes that associate with the RNA at the 5' end and reach the ORFs by a linear migration mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.