ReviewTrends in genetics : TIG2009
The W, X, Y and Z of sex-chromosome dosage compensation.
Review in Trends in genetics : TIG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed.
- Widespread male-female expression imbalance of X-linked genes across phrynosomatid lizards.Molecular biology and evolution · 2026Article
- Mixed Evidence that Dosage Sensitive Genes Drive Global Dosage Compensation in Flour Beetles.Genome biology and evolution · 2026Article
- Sex differences in endothelial cell biology: cellular phenotypes and molecular regulators.Frontiers in physiology · 2026Review
- The grasshopper genome reveals long-term gene content conservation of the X Chromosome and temporal variation in X Chromosome evolution.Genome research · 2024Article
- A maternal-to-zygotic-transition gene block on the zebrafish sex chromosome.G3 (Bethesda, Md.) · 2024Article
- Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation.PLoS biology · 2024Article
- The regulation of methylation on the Z chromosome and the identification of multiple novel Male Hyper-Methylated regions in the chicken.PLoS genetics · 2024Article
- Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.PLoS genetics · 2023Article
- Y chromosome sequence and epigenomic reconstruction across human populations.Communications biology · 2023Article
- X chromosomes show relaxed selection and complete somatic dosage compensation across Timema stick insect species.Journal of evolutionary biology · 2022Article
- A long noncoding RNA influences the choice of the X chromosome to be inactivated.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Do male and female heterogamety really differ in expression regulation? Lack of global dosage balance in pygopodid geckos.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Thermosensitive sex chromosome dosage compensation in ZZ/ZW softshell turtles,Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Sex-biased gene expression and recent sex chromosome turnover.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Rapid Evolution of Complete Dosage Compensation in Poecilia.Genome biology and evolution · 2021Article
- Review
- A gene's-eye view of sexual antagonism.Proceedings. Biological sciences · 2020Article
- Sex Chromosome Evolution: So Many Exceptions to the Rules.Genome biology and evolution · 2020Review
- Review
- Differential Gene Expression between Fungal Mating Types Is Associated with Sequence Degeneration.Genome biology and evolution · 2020Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
In species with highly differentiated sex chromosomes, imbalances in gene dosage between the sexes can affect overall organismal fitness. Regulatory mechanisms were discovered in several unrelated animals, which counter gene-dose differences between females and males, and these early findings suggested that dosage-compensating mechanisms were required for sex-chromosome evolution. However, recent reports in birds and moths contradict this view because these animals locally compensate only a few genes on the sex chromosomes, leaving the majority with different expression levels in males and females. These findings warrant a re-examination of the evolutionary forces underlying dosage compensation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.