ArticleThe EMBO journal1991
Axon-regulated expression of a Schwann cell transcript that is homologous to a 'growth arrest-specific' gene.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 184 citations in OpenAlex.
- Article
- Colocalization Analysis of Peripheral Myelin Protein-22 and Lamin-B1 in the Schwann Cell Nuclei of Wt and TrJ Mice.Biomolecules · 2022Article
- Central Alteration in Peripheral Neuropathy of Trembler-J Mice: Hippocampal pmp22 Expression and Behavioral Profile in Anxiety Tests.Biomolecules · 2021Article
- Plasmolipin and Its Role in Cell Processes.Molecular biology · 2021Article
- Review of the GAS3 Family of Proteins and their Relevance to Cancer.Critical reviews in oncogenesis · 2015Review
- Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast cancer cells.Molecular cancer · 2013Article
- The PMP22 gene and its related diseases.Molecular neurobiology · 2013Review
- Rewiring integrin-mediated signaling and cellular response with the peripheral myelin protein 22 and epithelial membrane protein 2 components of the tetraspan web.Investigative ophthalmology & visual science · 2011Article
- Understanding Schwann cell-neurone interactions: the key to Charcot-Marie-Tooth disease?Journal of anatomy · 2002Review
- Functional analysis for peripheral myelin protein PASII/PMP22: is it a member of claudin superfamily?Neurochemical research · 2001Article
- MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3.BMC cell biology · 2001Article
- Exposure at the cell surface is required for gas3/PMP22 To regulate both cell death and cell spreading: implication for the Charcot-Marie-Tooth type 1A and Dejerine-Sottas diseases.Molecular biology of the cell · 2000Article
- Uncoupling of myelin assembly and schwann cell differentiation by transgenic overexpression of peripheral myelin protein 22.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Clinical syndromes associated with tomacula or myelin swellings in sural nerve biopsies.Journal of neurology, neurosurgery, and psychiatry · 2000Article
- PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family.Genes & development · 2000Article
- Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22.Molecular biology of the cell · 1999Article
- Peripheral myelin protein 22 and protein zero: a novel association in peripheral nervous system myelin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Inherited neuropathies: from gene to disease.Brain pathology (Zurich, Switzerland) · 1999Review
- Nerve injury, axonal degeneration and neural regeneration: basic insights.Brain pathology (Zurich, Switzerland) · 1999Review
- Genetic aspects of Charcot-Marie-Tooth disease.Archives of disease in childhood · 1998Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated a 1.8 kb cDNA (pCD25) clone that encodes a transcript that is differentially expressed during nerve regeneration. Nucleotide sequence comparison indicates 89.6% homology with the recently identified murine 'growth arrest-specific' gene gas3. The open reading frame of the CD25 transcript predicts a 17 kDa protein with four putative transmembrane regions. Steady-state levels of the CD25 mRNA are very much higher in sciatic nerve than in other tissues, and expression in sciatic nerve is confined to Schwann cells. Following nerve injury, the transcript levels rapidly declined in nerve segments distal to the site of lesion, but recovered upon nerve regeneration. In contrast, in distal stumps of permanently transected nerves, the mRNA level remained very low. Substantial amounts of the mRNA could be reinduced only upon anastomosis of these interrupted nerve stumps. Re-induction of the mRNA followed the elongation of regenerating axons through the distal nerve segment. Our data indicate that axons regulate expression of the CD25 mRNA in Schwann cells, and suggest that the CD25 protein functions during Schwann cell growth and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.