Trial reportNutrition research (New York, N.Y.)2009
A Mediterranean dietary intervention in healthy American women changes plasma carotenoids and fatty acids in distinct clusters.
Trial report in Nutrition research (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00120016 (Design and Feasibility of a Mediterranean Diet), which is not on this map. Cited by 39 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Design and Feasibility of a Mediterranean Diet
Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Determinants of adherence to the Mediterranean diet among individuals with type 2 diabetes mellitus living in Mediterranean countries: a systematic review.Frontiers in nutrition · 2025Pooled it
- Biomarkers of dietary patterns: a systematic review of randomized controlled trials.Nutrition reviews · 2022Pooled it
- Pooled it
- Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2019Pooled it
- Dietary advice for reducing cardiovascular risk.The Cochrane database of systematic reviews · 2013Pooled it
- Trial
- Fatigue reduction diet in breast cancer survivors: a pilot randomized clinical trial.Breast cancer research and treatment · 2017Trial
- A community-based lifestyle and weight loss intervention promoting a Mediterranean-style diet pattern evaluated in the stroke belt of North Carolina: the Heart Healthy Lenoir Project.BMC public health · 2016Trial
- Sex differences in the impact of the Mediterranean diet on systemic inflammation.Nutrition journal · 2015Trial
- Effects of vitamin E from supplements and diet on colonic α- and γ-tocopherol concentrations in persons at increased colon cancer risk.Nutrition and cancer · 2015Trial
- Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2014Trial
- Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial.Cancer prevention research (Philadelphia, Pa.) · 2013Trial
- The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial.American journal of obstetrics and gynecology · 2013Trial
- Adherence to Mediterranean diet and close dietetic supervision increase total dietary antioxidant intake and plasma antioxidant capacity in subjects with abdominal obesity.European journal of nutrition · 2013Trial
- Lifestyle factors associated with serum N-3 fatty acid levels in breast cancer patients.Breast (Edinburgh, Scotland) · 2012Trial
- Cultural adaptations of food exchange lists: A scoping review of applications in non-communicable disease management.Asia Pacific journal of clinical nutrition · 2026Article
- Mediterranean diet impact on plasma proteins: biomarker networks linking nutrition to the modulation of inflammation and oxidative stress.Frontiers in nutrition · 2026Review
- Corporal Composition and Gut Microbiome Modification Through Exclusion Dietary Intervention in Adult Patients with Crohn's Disease: Protocol for a Prospective, Interventional, Controlled, Randomized Clinical Trial.Journal of clinical medicine · 2025Article
- Nutritional Barriers to the Adherence to the Mediterranean Diet in Non-Mediterranean Populations.Foods (Basel, Switzerland) · 2024Review
- Ten Recommendations for the Next Clinical Trial of the Mediterranean Diet in Inflamm-Aging: Results & Insights from a Scoping Review.JAR life · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This study examined patterns of changes in plasma fatty acids and carotenoids when women were asked to follow a novel, Greek-Mediterranean exchange list diet. A total of 69 healthy, nonobese women ages 25 to 59 years were randomized either to continue their own usual diet or to follow a modified Mediterranean diet for 6 months. There were no significant changes in blood lipids, triacylglycerol, insulin, glucose, or C-reactive protein. Mean plasma carotenoids increased by 55%, which is consistent with a large increase in fruit and vegetable consumption. Likewise, changes in fat intakes were reflected in blood fatty acids, with a 25% increase in mean plasma monounsaturated fatty acids. Principal component analysis was conducted to examine the sources of interindividual variation for changes in carotenoid and fatty acid levels. Changes in the Mediterranean diet were clustered together in 4 components that accounted for 78% of the variance in plasma levels. Increases in plasma lutein, alpha-carotene, and beta-carotene clustered together in a "vegetable" pattern, and increases in carotenoids found in fruit, beta-cryptoxanthin and zeaxanthin also clustered together but accounted for less of the variance. Increases in plasma monounsaturated fatty acids were clustered with a decrease in plasma polyunsaturated fatty acids, consistent with substitution in the type of oils consumed. The only association of fatty acid levels with carotenoids was that of lycopene, which clustered together with an increase in saturated fatty acids. The changes in blood levels indicate the exchange list diet was effective for targeting Mediterranean nutrient intakes using foods available in the United States.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.